Human Leukocyte Antigens in Undifferentiated Spondyloarthritis

Hsien Tzung Liao, Kuan Chia Lin, Chun Hsiung Chen, Toong Hua Liang, Ming Wei Lin, Chang Youh Tsai, David Tak Yan Yu, Chung Tei Chou

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objectives: Undifferentiated spondyloarthritis (USpA) is a major member of the spondyloarthritis family. Ankylosing spondylitis (AS), the prototype of the family, is a largely genetic disease, with human leukocyte antigens (HLA)-B27 being the essential gene. Other genes in the HLA region have also been implicated. The purpose of this study was to identify the alleles of the HLA-A, -B, -C, -DR, and -DQ, which are present at higher frequencies in USpA patients compared with an ethnically matched control population. Methods: Sixty-three Taiwanese patients with USpA were compared with 75 matched healthy controls. HLA typing was performed by polymerase chain reaction-sequence specific oligo-nucleotide genotyping. Results: The frequencies of HLA-B27, -B60, -C3, and -DR12 were strikingly higher in USpA patients compared with healthy subjects, with odds ratios of 75.4, 14.0, 9.6, and 7.0, respectively. When USpA patients with axial involvement were compared with those with peripheral arthritis, the following were more marginally frequent in those with axial involvement: HLA-B27 and -DR12 (odds ratios, 4.0 and 4.0, respectively). There was no association of HLA typing with other variables, including enthesitis, uveitis, erythrocyte sedimentation rate, and serum C-reactive protein. Interestingly, in 12 HLA-B27-negative USpA patients, HLA-B60, -C3, and -DR12 were more frequent compared with controls (odds ratios, 35, 16.2, and 8.1, respectively). Conclusions: Similar to AS, USpA is also linked to HLA-B27. A linkage to other HLA alleles observed here, even in our HLA-B27-negative USpA patients, strongly suggests that USpA in general is a genetic disease.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalSeminars in Arthritis and Rheumatism
Issue number3
Publication statusPublished - Dec 2007
Externally publishedYes


  • genetic study
  • human leukocyte antigen (HLA)
  • undifferentiated spondyloarthritis (USpA)

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Rheumatology


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