Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Sheng Fan Wang; Kuan Hsuan Chen; Marcelo Chen; Wen Yi Li; Yen Ju Chen; Ching Han Tsao; Muh Yong Yen; Jason C. Huang; Yi Ming Arthur Chen

doi:10.1089/vim.2011.0024

Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Sheng Fan Wang
, Kuan Hsuan Chen
, Marcelo Chen
, Wen Yi Li
, Yen Ju Chen
, Ching Han Tsao
, Muh Yong Yen
, Jason C. Huang
, Yi Ming Arthur Chen

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).

Original language	English
Pages (from-to)	421-426
Number of pages	6
Journal	Viral Immunology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1089/vim.2011.0024
Publication status	Published - Oct 1 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Immunology
Molecular Medicine
Virology

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10.1089/vim.2011.0024

Cite this

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title = "Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection",

abstract = "One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9\% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).",

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doi = "10.1089/vim.2011.0024",

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AU - Wang, Sheng Fan

AU - Chen, Kuan Hsuan

AU - Chen, Marcelo

AU - Li, Wen Yi

AU - Chen, Yen Ju

AU - Tsao, Ching Han

AU - Yen, Muh Yong

AU - Huang, Jason C.

AU - Chen, Yi Ming Arthur

PY - 2011/10/1

Y1 - 2011/10/1

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AB - One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3y after the SARS outbreaks in Taiwan. Western blot assay showed that 6.9% of participants still had anti-spike and anti-nucleocapside antibodies. A case-control study of the association of HLA with SARS revealed that the HLA-Cw1502 and DR0301 alleles conferred resistance against SARS infection (p<0.05).

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SN - 0882-8245

VL - 24

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EP - 426

JO - Viral Immunology

JF - Viral Immunology

IS - 5

ER -

Human-leukocyte antigen class i Cw 1502 and Class II DR 0301 genotypes are associated with resistance to severe acute respiratory syndrome (SARS) infection

Abstract

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ASJC Scopus subject areas

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