HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

HIN‐WING ‐W YEUNG; DONALD YAMASHIRO; LIANG‐FU ‐F TSENG; WEN‐CHANG ‐C CHANG; CHOH HAO LI

doi:10.1111/j.1399-3011.1981.tb01987.x

HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

HIN‐WING ‐W YEUNG
, DONALD YAMASHIRO
, LIANG‐FU ‐F TSENG
, WEN‐CHANG ‐C CHANG
, CHOH HAO LI

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Four analogs of the opioid peptide human β‐endorphin (β_h‐EP) have been synthesized: [d‐Lys⁹,Phe²⁷,Gly³¹]‐β_h‐EP, [d‐Phe¹⁸,Phe²⁷,Gly³¹)‐β_h‐EP, [d‐Thr²,d‐Lys⁹,Phe²⁷,Gly³¹]‐β_h‐EP, and [d‐Thr²,d‐Phe¹⁸,Phe²⁷,Gly³¹]‐β_h‐EP. All are practically indistinguishable from β_h‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.

Original language	English
Pages (from-to)	235-238
Number of pages	4
Journal	International Journal of Peptide and Protein Research
Volume	17
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-3011.1981.tb01987.x
Publication status	Published - Jan 1 1981
Externally published	Yes

Keywords

guinea pig ileum assay
mouse tail‐flick test
solid‐phase peptide synthesis
β‐endorphin analogs

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1399-3011.1981.tb01987.x

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title = "HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31",

abstract = "Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.",

keywords = "guinea pig ileum assay, mouse tail‐flick test, solid‐phase peptide synthesis, β‐endorphin analogs",

author = "YEUNG, \{HIN‐WING ‐W\} and DONALD YAMASHIRO and TSENG, \{LIANG‐FU ‐F\} and CHANG, \{WEN‐CHANG ‐C\} and LI, \{CHOH HAO\}",

year = "1981",

month = jan,

day = "1",

doi = "10.1111/j.1399-3011.1981.tb01987.x",

language = "English",

volume = "17",

pages = "235--238",

journal = "International Journal of Peptide and Protein Research",

issn = "0367-8377",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

TY - JOUR

T1 - HUMAN β‐ENDORPHIN

T2 - SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

AU - YEUNG, HIN‐WING ‐W

AU - YAMASHIRO, DONALD

AU - TSENG, LIANG‐FU ‐F

AU - CHANG, WEN‐CHANG ‐C

AU - LI, CHOH HAO

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.

AB - Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.

KW - guinea pig ileum assay

KW - mouse tail‐flick test

KW - solid‐phase peptide synthesis

KW - β‐endorphin analogs

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UR - https://www.scopus.com/pages/publications/0019862013#tab=citedBy

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DO - 10.1111/j.1399-3011.1981.tb01987.x

M3 - Article

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AN - SCOPUS:0019862013

SN - 0367-8377

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EP - 238

JO - International Journal of Peptide and Protein Research

JF - International Journal of Peptide and Protein Research

IS - 2

ER -

HUMAN β‐ENDORPHIN: SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31

Abstract

Keywords

ASJC Scopus subject areas

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