TY - JOUR
T1 - HUMAN β‐ENDORPHIN
T2 - SYNTHESIS AND BIOLOGICAL ACTIVITY OF ANALOGS WITH SUBSTITUTIONS IN POSITIONS 2, 9, 18, 27 AND 31
AU - YEUNG, HIN‐WING ‐W
AU - YAMASHIRO, DONALD
AU - TSENG, LIANG‐FU ‐F
AU - CHANG, WEN‐CHANG ‐C
AU - LI, CHOH HAO
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.
AB - Four analogs of the opioid peptide human β‐endorphin (βh‐EP) have been synthesized: [d‐Lys9,Phe27,Gly31]‐βh‐EP, [d‐Phe18,Phe27,Gly31)‐βh‐EP, [d‐Thr2,d‐Lys9,Phe27,Gly31]‐βh‐EP, and [d‐Thr2,d‐Phe18,Phe27,Gly31]‐βh‐EP. All are practically indistinguishable from βh‐EP in the guinea pig ileum assay. All show diminished analgesic potency in the mouse tail‐flick assay.
KW - guinea pig ileum assay
KW - mouse tail‐flick test
KW - solid‐phase peptide synthesis
KW - β‐endorphin analogs
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U2 - 10.1111/j.1399-3011.1981.tb01987.x
DO - 10.1111/j.1399-3011.1981.tb01987.x
M3 - Article
C2 - 6262258
AN - SCOPUS:0019862013
SN - 0367-8377
VL - 17
SP - 235
EP - 238
JO - International Journal of Peptide and Protein Research
JF - International Journal of Peptide and Protein Research
IS - 2
ER -