HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths

WEN‐CHANG ‐C CHANG; HIN‐WING ‐W YEUNG; CHOH HAO LI

doi:10.1111/j.1399-3011.1979.tb01880.x

HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths

WEN‐CHANG ‐C CHANG, HIN‐WING ‐W YEUNG, CHOH HAO LI

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Immunoreactivity of synthetic human β‐endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that β‐endorphin‐(1–21) and analogs of shortened chain exhibit no immunoreactivity, whereas β‐endorphin‐(1–15) possesses significant in vitro opiate activity. It appears that immunoreactivity of β‐endorphin resides in the COOH‐terminal segment of residues (22–31). The data also show the lack of correlation between opiate and immunological activities of β‐endorphin.

Original language	English
Pages (from-to)	278-281
Number of pages	4
Journal	International Journal of Peptide and Protein Research
Volume	13
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-3011.1979.tb01880.x
Publication status	Published - Jan 1 1979
Externally published	Yes

Keywords

opiate activity
radioimmunoassay
β‐lipotropin

ASJC Scopus subject areas

Biochemistry

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10.1111/j.1399-3011.1979.tb01880.x

Cite this

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title = "HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths",

abstract = "Immunoreactivity of synthetic human β‐endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that β‐endorphin‐(1–21) and analogs of shortened chain exhibit no immunoreactivity, whereas β‐endorphin‐(1–15) possesses significant in vitro opiate activity. It appears that immunoreactivity of β‐endorphin resides in the COOH‐terminal segment of residues (22–31). The data also show the lack of correlation between opiate and immunological activities of β‐endorphin.",

keywords = "opiate activity, radioimmunoassay, β‐lipotropin",

author = "CHANG, {WEN‐CHANG ‐C} and YEUNG, {HIN‐WING ‐W} and LI, {CHOH HAO}",

year = "1979",

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AU - YEUNG, HIN‐WING ‐W

AU - LI, CHOH HAO

PY - 1979/1/1

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N2 - Immunoreactivity of synthetic human β‐endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that β‐endorphin‐(1–21) and analogs of shortened chain exhibit no immunoreactivity, whereas β‐endorphin‐(1–15) possesses significant in vitro opiate activity. It appears that immunoreactivity of β‐endorphin resides in the COOH‐terminal segment of residues (22–31). The data also show the lack of correlation between opiate and immunological activities of β‐endorphin.

AB - Immunoreactivity of synthetic human β‐endorphin analogs with various chain lengths has been examined using a specific radioimmunoassay. It was found that β‐endorphin‐(1–21) and analogs of shortened chain exhibit no immunoreactivity, whereas β‐endorphin‐(1–15) possesses significant in vitro opiate activity. It appears that immunoreactivity of β‐endorphin resides in the COOH‐terminal segment of residues (22–31). The data also show the lack of correlation between opiate and immunological activities of β‐endorphin.

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KW - radioimmunoassay

KW - β‐lipotropin

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HUMAN β‐ENDORPHIN Immunoreactivity of Synthetic Analogs with Various Chain Lengths

Abstract

Keywords

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