TY - JOUR
T1 - HPV-associated lung cancers
T2 - An international pooled analysis
AU - Ragin, Camille
AU - Obikoya-Malomo, Monisola
AU - Kim, Sungjin
AU - Chen, Zhengjia
AU - Flores-Obando, Rafael
AU - Gibbs, Denise
AU - Koriyama, Chihaya
AU - Aguayo, Francisco
AU - Koshiol, Jill
AU - Caporaso, Neil E.
AU - Carpagnano, Giovanna E.
AU - Ciotti, Marco
AU - Dosaka-Akita, Hirotoshi
AU - Fukayama, Masashi
AU - Goto, Akiteru
AU - Spandidos, Demetrios A.
AU - Gorgoulis, Vassilis
AU - Heideman, Daniëlle A M
AU - van Boerdonk, Robert A A
AU - Hiroshima, Kenzo
AU - Iwakawa, Reika
AU - Kastrinakis, Nikolaos G.
AU - Kinoshita, Ichiro
AU - Akiba, Suminori
AU - Landi, Maria T.
AU - Eugene Liu, H.
AU - Wang, Jinn-Li
AU - Mehra, Ranee
AU - Khuri, Fadlo R.
AU - Lim, Wan Teck
AU - Owonikoko, Taofeek K.
AU - Ramalingam, Suresh
AU - Sarchianaki, Emmanuela
AU - Syrjanen, Kari
AU - Tsao, Ming Sound
AU - Sykes, Jenna
AU - Hee, Siew Wan
AU - Yokota, Jun
AU - Zaravinos, Apostolos
AU - Taioli, Emanuela
N1 - Publisher Copyright:
© The Author 2014. Published by Oxford University Press. All rights reserved.
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of cross-sectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship. Published by Oxford University Press 2014.
AB - Human papillomavirus (HPV) is the etiologic risk factor for cervical cancer. Some studies have suggested an association with a subset of lung tumors, but the etiologic link has not been firmly established. We performed an international pooled analysis of cross-sectional studies (27 datasets, n = 3249 patients) to evaluate HPV DNA prevalence in lung cancer and to investigate viral presence according to clinical and demographic characteristics. HPV16/18 were the most commonly detected, but with substantial variation in viral prevalence between geographic regions. The highest prevalence of HPV16/18 was observed in South and Central America, followed by Asia, North America and Europe (adjusted prevalence rates = 22, 5, 4 and 3%, respectively). Higher HPV16 prevalence was noted in each geographic region compared with HPV18, except in North America. HPV16/18-positive lung cancer was less likely observed among White race (adjusted odds ratio [OR] = 0.33, 95% confidence interval [CI] = 0.12-0.90), whereas no associations were observed with gender, smoking history, age, histology or stage. Comparisons between tumor and normal lung tissue show that HPV was more likely to be present in lung cancer rather than normal lung tissues (OR = 3.86, 95% CI = 2.87-5.19). Among a subset of patients with HPV16-positive tumors, integration was primarily among female patients (93%, 13/14), while the physical status in male cases (N = 14) was inconsistent. Our findings confirm that HPV DNA is present in a small fraction of lung tumors, with large geographic variations. Further comprehensive analysis is needed to assess whether this association reflects a causal relationship. Published by Oxford University Press 2014.
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U2 - 10.1093/carcin/bgu038
DO - 10.1093/carcin/bgu038
M3 - Article
C2 - 24523449
AN - SCOPUS:84905092087
SN - 0143-3334
VL - 35
SP - 1267
EP - 1275
JO - Carcinogenesis
JF - Carcinogenesis
IS - 6
ER -