Abstract
Anti-hypertensive medications may affect plasma renin activity and/or plasma aldosterone concentration, misleading the interpretation of the aldosterone-to-renin ratio when screening for primary aldosteronism. The Task Force of Taiwan PA recommends that, when necessary, using α-adrenergic receptor blocking agents, centrally acting α-adrenergic agonists, and/or non-dihydropyridine calcium channel blockers should be considered to control blood pressure before screening for PA. We recommend temporarily holding β-adrenergic receptor blocking agents, mineralocorticoid receptor antagonists, dihydropyridine calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and all diuretics before screening for PA. Further large-scale randomized controlled studies are required to confirm the recommendations.
Original language | English |
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Pages (from-to) | S91-S97 |
Journal | Journal of the Formosan Medical Association |
Volume | 123 |
DOIs | |
Publication status | Published - Mar 2024 |
Keywords
- Aldosterone-to-renin ratio
- Anti-hypertensive medications
- Centrally acting α-adrenergic agonists
- Nondihydropyridine calcium channel blockers
- Primary aldosteronism
- α-adrenergic receptor blocking agents
ASJC Scopus subject areas
- General Medicine