HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer

Yi Ting Chang; Tzu Ping Lin; Jui Ting Tang; Mel Campbell; Yun Li Luo; Shih Yen Lu; Chia Pei Yang; Ting Yu Cheng; Ching Hsin Chang; Tze Tze Liu; Chi Hung Lin; Hsing Jein Kung; Chin Chen Pan; Pei Ching Chang

doi:10.1016/j.canlet.2018.06.029

HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer

Yi Ting Chang, Tzu Ping Lin, Jui Ting Tang, Mel Campbell, Yun Li Luo, Shih Yen Lu, Chia Pei Yang, Ting Yu Cheng, Ching Hsin Chang, Tze Tze Liu, Chi Hung Lin, Hsing Jein Kung, Chin Chen Pan, Pei Ching Chang

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52 Citations (Scopus)

Abstract

Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and metastatic form of PCa. In addition to androgen receptor (AR) signaling, neuroendocrine differentiation (NED) is associated with CRPC. Recent reports demonstrate that the downregulation of repressor element-1 silencing transcription factor (REST) protein is a key step in NED of PCa cells. Here, we report HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC. HOTAIR overexpression is sufficient to induce, whereas knockdown of HOTAIR suppressed NED of PCa cells. Gene ontology (GO) analysis of differentially expressed genes under HOTAIR overexpression and in CRPC versus benign prostatic hyperplasia (BPH) suggests that HOTAIR may participate in PCa progression. Taken together, our results provide the first evidence of lncRNA HOTAIR as a driver for NED of PCa cells.

Original language	English
Pages (from-to)	43-52
Number of pages	10
Journal	Cancer Letters
Volume	433
DOIs	https://doi.org/10.1016/j.canlet.2018.06.029
Publication status	Published - Oct 1 2018

Keywords

Castration-resistant prostate cancer
HOTAIR
Long non-coding RNAs
Neuroendocrine differentiation
REST

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2018.06.029

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Chang, Y. T., Lin, T. P., Tang, J. T., Campbell, M., Luo, Y. L., Lu, S. Y., Yang, C. P., Cheng, T. Y., Chang, C. H., Liu, T. T., Lin, C. H., Kung, H. J., Pan, C. C., & Chang, P. C. (2018). HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer. Cancer Letters, 433, 43-52. https://doi.org/10.1016/j.canlet.2018.06.029

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title = "HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer",

abstract = "Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and metastatic form of PCa. In addition to androgen receptor (AR) signaling, neuroendocrine differentiation (NED) is associated with CRPC. Recent reports demonstrate that the downregulation of repressor element-1 silencing transcription factor (REST) protein is a key step in NED of PCa cells. Here, we report HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC. HOTAIR overexpression is sufficient to induce, whereas knockdown of HOTAIR suppressed NED of PCa cells. Gene ontology (GO) analysis of differentially expressed genes under HOTAIR overexpression and in CRPC versus benign prostatic hyperplasia (BPH) suggests that HOTAIR may participate in PCa progression. Taken together, our results provide the first evidence of lncRNA HOTAIR as a driver for NED of PCa cells.",

keywords = "Castration-resistant prostate cancer, HOTAIR, Long non-coding RNAs, Neuroendocrine differentiation, REST",

author = "Chang, {Yi Ting} and Lin, {Tzu Ping} and Tang, {Jui Ting} and Mel Campbell and Luo, {Yun Li} and Lu, {Shih Yen} and Yang, {Chia Pei} and Cheng, {Ting Yu} and Chang, {Ching Hsin} and Liu, {Tze Tze} and Lin, {Chi Hung} and Kung, {Hsing Jein} and Pan, {Chin Chen} and Chang, {Pei Ching}",

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year = "2018",

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doi = "10.1016/j.canlet.2018.06.029",

language = "English",

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journal = "Cancer Letters",

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T1 - HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer

AU - Chang, Yi Ting

AU - Lin, Tzu Ping

AU - Tang, Jui Ting

AU - Campbell, Mel

AU - Luo, Yun Li

AU - Lu, Shih Yen

AU - Yang, Chia Pei

AU - Cheng, Ting Yu

AU - Chang, Ching Hsin

AU - Liu, Tze Tze

AU - Lin, Chi Hung

AU - Kung, Hsing Jein

AU - Pan, Chin Chen

AU - Chang, Pei Ching

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and metastatic form of PCa. In addition to androgen receptor (AR) signaling, neuroendocrine differentiation (NED) is associated with CRPC. Recent reports demonstrate that the downregulation of repressor element-1 silencing transcription factor (REST) protein is a key step in NED of PCa cells. Here, we report HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC. HOTAIR overexpression is sufficient to induce, whereas knockdown of HOTAIR suppressed NED of PCa cells. Gene ontology (GO) analysis of differentially expressed genes under HOTAIR overexpression and in CRPC versus benign prostatic hyperplasia (BPH) suggests that HOTAIR may participate in PCa progression. Taken together, our results provide the first evidence of lncRNA HOTAIR as a driver for NED of PCa cells.

AB - Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and metastatic form of PCa. In addition to androgen receptor (AR) signaling, neuroendocrine differentiation (NED) is associated with CRPC. Recent reports demonstrate that the downregulation of repressor element-1 silencing transcription factor (REST) protein is a key step in NED of PCa cells. Here, we report HOTAIR as a novel REST-repressed lncRNA that is upregulated in NED PCa cells and in CRPC. HOTAIR overexpression is sufficient to induce, whereas knockdown of HOTAIR suppressed NED of PCa cells. Gene ontology (GO) analysis of differentially expressed genes under HOTAIR overexpression and in CRPC versus benign prostatic hyperplasia (BPH) suggests that HOTAIR may participate in PCa progression. Taken together, our results provide the first evidence of lncRNA HOTAIR as a driver for NED of PCa cells.

KW - Castration-resistant prostate cancer

KW - HOTAIR

KW - Long non-coding RNAs

KW - Neuroendocrine differentiation

KW - REST

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JO - Cancer Letters

JF - Cancer Letters

ER -

HOTAIR is a REST-regulated lncRNA that promotes neuroendocrine differentiation in castration resistant prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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