Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1230-1247 |
| Number of pages | 18 |
| Journal | Cell Research |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 |
| Externally published | Yes |
Keywords
- chromatin assembly factor 1
- chromatin structure
- human cytomegalovirus
- immediate-early protein 2
- histone
- IE2 protein, Cytomegalovirus
- immediate early protein
- transactivator protein
- virus DNA
- amino acid substitution
- article
- cell line
- chromatin
- chromatin assembly and disassembly
- Cytomegalovirus
- genetics
- host pathogen interaction
- human
- metabolism
- protein binding
- protein subunit
- virus replication
- Amino Acid Substitution
- Cell Line
- Chromatin
- Chromatin Assembly and Disassembly
- Chromatin Assembly Factor-1
- DNA, Viral
- Histones
- Host-Pathogen Interactions
- Humans
- Immediate-Early Proteins
- Protein Binding
- Protein Subunits
- Trans-Activators
- Virus Replication
- Human herpesvirus 5
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In: Cell Research, Vol. 21, No. 8, 2011, p. 1230-1247.
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}
TY - JOUR
T1 - Host-viral effects of chromatin assembly factor 1 interaction with HCMV IE2
AU - Lee, Sung-Bau
AU - Lee, Chung-Fan
AU - Ou, Derick S C
AU - Dulal, Kalpana
AU - Chang, Liang-Hao
AU - Ma, Chen-Han
AU - Huang, Chien-Fu
AU - Zhu, Hua
AU - Lin, Young-Sun
AU - Juan, Li-Jung
N1 - 被引用次數：4 Export Date: 28 March 2016 通訊地址: Juan, L.-J.; Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; 電子郵件： [email protected] 化學物質/CAS: histone, 9062-68-4; Chromatin; Chromatin Assembly Factor-1; DNA, Viral; Histones; IE2 protein, Cytomegalovirus; Immediate-Early Proteins; Protein Subunits; Trans-Activators 參考文獻: Smith, S., Stillman, B., Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro (1989) Cell, 58 (1), pp. 15-25. , DOI 10.1016/0092-8674(89)90398-X; Li, Q., Zhou, H., Wurtele, H., Davies, B., Horazdovsky, B., Verreault, A., Zhang, Z., Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly (2008) Cell, 134 (2), pp. 244-255. , DOI 10.1016/j.cell.2008.06.018, PII S0092867408007708; Takami, Y., Ono, T., Fukagawa, T., Shibahara, K.-I., Nakayama, T., Essential role of chromatin assembly factor-1-mediated rapid nucleosome assembly for DNA replication and cell division in vertebrate cells (2007) Molecular Biology of the Cell, 18 (1), pp. 129-141. , DOI 10.1091/mbc.E06-05-0426; 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PY - 2011
Y1 - 2011
N2 - Chromatin assembly factor 1 (CAF1) consisting of p150, p60 and p48 is known to assemble histones onto newly synthesized DNA and thus maintain the chromatin structure. Here, we show that CAF1 expression was induced in human cytomegalovirus (HCMV)-infected cells, concomitantly with global chromatin decondensation. This apparent conflict was thought to result, in part, from CAF1 mislocalization to compartments of HCMV DNA synthesis through binding of its largest subunit p150 to viral immediate-early protein 2 (IE2). p150 interaction with p60 and IE2 facilitated HCMV DNA synthesis. The IE2Q548R mutation, previously reported to result in impaired HCMV growth with unknown mechanism, disrupted IE2/p150 and IE2/histones association in our study. Moreover, IE2 interaction with histones partly depends on p150, and the HCMV-induced chromatin decondensation was reduced in cells ectopically expressing the p150 mutant defective in IE2 binding. These results not only indicate that CAF1 was hijacked by IE2 to facilitate the replication of the HCMV genome, suggesting chromatin assembly plays an important role in herpesviral DNA synthesis, but also provide a model of the virus-induced chromatin instability through CAF1. © 2011 IBCB, SIBS, CAS All rights reserved.
AB - Chromatin assembly factor 1 (CAF1) consisting of p150, p60 and p48 is known to assemble histones onto newly synthesized DNA and thus maintain the chromatin structure. Here, we show that CAF1 expression was induced in human cytomegalovirus (HCMV)-infected cells, concomitantly with global chromatin decondensation. This apparent conflict was thought to result, in part, from CAF1 mislocalization to compartments of HCMV DNA synthesis through binding of its largest subunit p150 to viral immediate-early protein 2 (IE2). p150 interaction with p60 and IE2 facilitated HCMV DNA synthesis. The IE2Q548R mutation, previously reported to result in impaired HCMV growth with unknown mechanism, disrupted IE2/p150 and IE2/histones association in our study. Moreover, IE2 interaction with histones partly depends on p150, and the HCMV-induced chromatin decondensation was reduced in cells ectopically expressing the p150 mutant defective in IE2 binding. These results not only indicate that CAF1 was hijacked by IE2 to facilitate the replication of the HCMV genome, suggesting chromatin assembly plays an important role in herpesviral DNA synthesis, but also provide a model of the virus-induced chromatin instability through CAF1. © 2011 IBCB, SIBS, CAS All rights reserved.
KW - chromatin assembly factor 1
KW - chromatin structure
KW - human cytomegalovirus
KW - immediate-early protein 2
KW - histone
KW - IE2 protein, Cytomegalovirus
KW - immediate early protein
KW - transactivator protein
KW - virus DNA
KW - amino acid substitution
KW - article
KW - cell line
KW - chromatin
KW - chromatin assembly and disassembly
KW - Cytomegalovirus
KW - genetics
KW - host pathogen interaction
KW - human
KW - metabolism
KW - protein binding
KW - protein subunit
KW - virus replication
KW - Amino Acid Substitution
KW - Cell Line
KW - Chromatin
KW - Chromatin Assembly and Disassembly
KW - Chromatin Assembly Factor-1
KW - DNA, Viral
KW - Histones
KW - Host-Pathogen Interactions
KW - Humans
KW - Immediate-Early Proteins
KW - Protein Binding
KW - Protein Subunits
KW - Trans-Activators
KW - Virus Replication
KW - Human herpesvirus 5
U2 - 10.1038/cr.2011.53
DO - 10.1038/cr.2011.53
M3 - Article
SN - 1001-0602
VL - 21
SP - 1230
EP - 1247
JO - Cell Research
JF - Cell Research
IS - 8
ER -