Host and viral factors in relation to clearance of human papillomavirus infection: A cohort study in Taiwan

Chyong Huey Lai, Angel Chao, Chee Jen Chang, Fang Yu Chao, Huei Jean Huang, Swei Hsueh, Cheng Tao Lin, Hui Hsin Cheng, Chu Chun Huang, Jung Erh Yang, Tzu I. Wu, Hung Hsueh Chou, Ting Chang Chang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Human papillomavirus (HPV) persistence is essential for cervical cancer development. We accrued nested-cohort subjects from a population-based study to investigate the host and viral factors related to outcome of HPV infection. Women (age ≥ 30 years old) with HPV-positive but normal cytology and negative colposcopy were invited to participate. After signing informed consent, every participant completed a structured questionnaire and had 6-monthly follow-ups of Pap smear, HPV testing and colposcopy. Total and type-specific HPV clearance rates as well as host and viral factors associated with clearance in 3-year longitudinal follow-up were analyzed. Adjusted hazard ratios (HRs) of progression to ≥ cervical intraepithelial neoplasia (CIN) 2 according to baseline HPV of the women with normal cytology were calculated from national registry database. Among the 626 eligible women, 526 (median age 47, 29-75) were enrolled and 412 returned for follow-up at least once. The median follow-up of enrolled subjects was 23 months (range 6.8-39). The 3-year cumulative total HPV clearance rate was 49.0% (95% confidence interval [CI]: 43.3-54.7%). The median 3-year cumulative type-specific HPV clearance rate was 50.0% (range 0-100.0%) with a median time to clearance of 12.4 months (6.4-24.5). Older age was associated with significantly decreased total HPV clearance and decreased type-specific clearance in HPV-18 and -53, while high viral load was associated with decreased total and type-specific clearance. After adjusting confounding variables, the HR of developing ≥CIN2 in baseline HPV-positive women was 34.0-fold (95% CI: 15.5-74.7) as compared to HPV-negative women.

Original languageEnglish
Pages (from-to)1685-1692
Number of pages8
JournalInternational Journal of Cancer
Issue number7
Publication statusPublished - Oct 1 2008
Externally publishedYes


  • Clearance
  • Genotype
  • Human papillomavirus
  • Viral load

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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