TY - JOUR
T1 - Honokiol induces apoptotic cell death by oxidative burst and mitochondrial hyperpolarization of bladder cancer cells
T2 - Experimental and Therapeutic Medicine
AU - Hsiao, Chi‑Hao
AU - Yao, Chih‑Jung
AU - Lai, Gi‑Ming
AU - Lee, Liang‑Ming
AU - Whang‑Peng, Jacqueline
AU - Shih, Ping‑Hsiao
PY - 2019
Y1 - 2019
N2 - Bladder cancer is one of the most common types of malignant tumor worldwide. Current treatments, including chemo‑/radiotherapy, only have limited efficacy on bladder cancer progression. Honokiol is an active component of Magnolia officinalis with multiple biological effects that may provide promising health benefits. In the present study, the anti‑cancer properties of honokiol against bladder cancer cells were investigated by flow cytometric analysis. The results revealed that honokiol exhibited significant anti‑proliferative effects on bladder cancer cell lines, particularly on BFTC‑905 human transitional cell carcinoma cells. Furthermore, honokiol at low doses (≤25 µM) induced cell cycle arrest in G0/G1 phase, while it induced significant apoptotic cell death at high doses (≥50 µM; P
AB - Bladder cancer is one of the most common types of malignant tumor worldwide. Current treatments, including chemo‑/radiotherapy, only have limited efficacy on bladder cancer progression. Honokiol is an active component of Magnolia officinalis with multiple biological effects that may provide promising health benefits. In the present study, the anti‑cancer properties of honokiol against bladder cancer cells were investigated by flow cytometric analysis. The results revealed that honokiol exhibited significant anti‑proliferative effects on bladder cancer cell lines, particularly on BFTC‑905 human transitional cell carcinoma cells. Furthermore, honokiol at low doses (≤25 µM) induced cell cycle arrest in G0/G1 phase, while it induced significant apoptotic cell death at high doses (≥50 µM; P
KW - magnolia officinalis honokiol bladder cancer flow cytometry apoptosis oxidative stress mitochondrial membrane hyperpolarization
U2 - 10.3892/etm.2019.7419
DO - 10.3892/etm.2019.7419
M3 - 文章
SN - 1792-0981
VL - 17
SP - 4213
EP - 4222
JO - Experimental and Therapeutic Medicine
JF - Experimental and Therapeutic Medicine
IS - 5
ER -