TY - JOUR
T1 - HIV Infection Increases the Risk of Incident Psoriasis
T2 - A Nationwide Population-Based Cohort Study in Taiwan
AU - Yen, Yung Feng
AU - Jen, I. An
AU - Chen, Marcelo
AU - Lan, Yu Ching
AU - Lee, Chun Yuan
AU - Chuang, Pei Hung
AU - Lee, Yun
AU - Arthur Chen, Yi Ming
N1 - Publisher Copyright:
© Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017/8/15
Y1 - 2017/8/15
N2 - Background: HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied. Objectives: The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis. Methods: Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database. A control cohort without HIV infection, matched for age and sex, was selected for comparison. All patients were followed until December 31, 2012, and observed for the occurrence of psoriasis. The time-dependent Cox proportional hazards model was used to determine the association of HIV with incident psoriasis, while considering death as a competing risk event. Results: Of the 102,070 patients (20,294 PLWHA and 81,776 matched controls), 248 (0.24%) had incident psoriasis during a mean follow-up period of 5.53 years, including 81 (0.40%) PLWHA and 171 (0.21%) controls. After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident psoriasis (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38 to 2.36). Conclusions: The population of PLWHA is living longer; clinicians need to be aware of their higher risk of psoriasis.
AB - Background: HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied. Objectives: The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis. Methods: Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database. A control cohort without HIV infection, matched for age and sex, was selected for comparison. All patients were followed until December 31, 2012, and observed for the occurrence of psoriasis. The time-dependent Cox proportional hazards model was used to determine the association of HIV with incident psoriasis, while considering death as a competing risk event. Results: Of the 102,070 patients (20,294 PLWHA and 81,776 matched controls), 248 (0.24%) had incident psoriasis during a mean follow-up period of 5.53 years, including 81 (0.40%) PLWHA and 171 (0.21%) controls. After adjusting for age, sex, and comorbidities, HIV infection was found to be an independent risk factor for incident psoriasis (adjusted hazard ratio, 1.80; 95% confidence interval: 1.38 to 2.36). Conclusions: The population of PLWHA is living longer; clinicians need to be aware of their higher risk of psoriasis.
KW - cohort
KW - HIV
KW - psoriasis
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U2 - 10.1097/QAI.0000000000001431
DO - 10.1097/QAI.0000000000001431
M3 - Article
C2 - 28692580
AN - SCOPUS:85025598874
SN - 1525-4135
VL - 75
SP - 493
EP - 499
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 5
ER -
