TY - JOUR
T1 - High Serum Leptin Is Associated with Low eGFR but Not Proteinuria in Chronic Kidney Disease: A Community-Based Study
AU - She, Yun-Hsuan
AU - Sun, Chiao-Yin
AU - Lee, Chin-Chan
AU - Chen, Chun-Yu
AU - Hsu, Heng-Rong
AU - Chen, Yuen-Chan
AU - Chen, Li-Wei
AU - Shyu, Yu-Chiau
AU - Wu, I-Wen
PY - 2021/3/1
Y1 - 2021/3/1
N2 - BACKGROUND: Both obesity and chronic kidney disease (CKD) are important global public health challenges. Investigations of putative mediators to break down the vicious cycle among imbalance of homeostasis, obesity, and CKD remain mandatory to alleviate the burden of two diseases. Several adipokines were proposed to have a mechanistic implication on developments of this disease; however, the exact association between serum leptin and CKD remains unclear. METHODS: In this community-based study, we studied the association between serum leptin level and the estimated glomerular filtration rate (eGFR) and proteinuria in 4,071 habitants of communities of Northwestern Taiwan. The correlation was used to evaluate the relationship of log serum level with different biochemical parameters. Logistic regression analysis was applied to elucidate the association between serum leptin and the outcome of interest. RESULTS: The mean age was 57.61 years, mean eGFR was 94.94 ± 25.79 mL/min/1.73 m^2 and 34.78% were males. Diabetes was present in 16.14% of all participants. The prevalence of CKD was 18%. CKD patients were more likely to have higher serum leptin levels, low education levels, older age, diabetes, obesity, metabolic syndrome, hypertension (HTN), and cardiovascular disease. Log leptin was significantly positively correlated with eGFR, hemoglobin, phosphate, chloride, carbon dioxide, albumin, cholesterol, low-density lipoprotein, triglyceride, log intact parathyroid hormone, log vitamin D, log high sensitivity C-reactive protein (hs-CRP), microalbuminuria, systolic and diastolic pressure, waist circumference, body mass index, and insulin resistance. Multivariate logistic regression analysis revealed independent association of log serum leptin with eGFR ＜ 60 mL/min (odds ratio [OR], 1.618; 95% confidence interval [CI], 1.311-1.997; P ＜ 0.001) but not for proteinuria (OR, 1.034; 95% CI, 0.933-1.147; P = 0.524), after adjusting log leptin with age, gender, diabetes, HTN, cardiovascular disease, gout, albumin, hemoglobin, log hs-CRP, obesity, and metabolic syndrome. CONCLUSIONS: Serum leptin may represent a novel serum biomarker for diagnosis of CKD, in addition to other many traditional risk factors.
AB - BACKGROUND: Both obesity and chronic kidney disease (CKD) are important global public health challenges. Investigations of putative mediators to break down the vicious cycle among imbalance of homeostasis, obesity, and CKD remain mandatory to alleviate the burden of two diseases. Several adipokines were proposed to have a mechanistic implication on developments of this disease; however, the exact association between serum leptin and CKD remains unclear. METHODS: In this community-based study, we studied the association between serum leptin level and the estimated glomerular filtration rate (eGFR) and proteinuria in 4,071 habitants of communities of Northwestern Taiwan. The correlation was used to evaluate the relationship of log serum level with different biochemical parameters. Logistic regression analysis was applied to elucidate the association between serum leptin and the outcome of interest. RESULTS: The mean age was 57.61 years, mean eGFR was 94.94 ± 25.79 mL/min/1.73 m^2 and 34.78% were males. Diabetes was present in 16.14% of all participants. The prevalence of CKD was 18%. CKD patients were more likely to have higher serum leptin levels, low education levels, older age, diabetes, obesity, metabolic syndrome, hypertension (HTN), and cardiovascular disease. Log leptin was significantly positively correlated with eGFR, hemoglobin, phosphate, chloride, carbon dioxide, albumin, cholesterol, low-density lipoprotein, triglyceride, log intact parathyroid hormone, log vitamin D, log high sensitivity C-reactive protein (hs-CRP), microalbuminuria, systolic and diastolic pressure, waist circumference, body mass index, and insulin resistance. Multivariate logistic regression analysis revealed independent association of log serum leptin with eGFR ＜ 60 mL/min (odds ratio [OR], 1.618; 95% confidence interval [CI], 1.311-1.997; P ＜ 0.001) but not for proteinuria (OR, 1.034; 95% CI, 0.933-1.147; P = 0.524), after adjusting log leptin with age, gender, diabetes, HTN, cardiovascular disease, gout, albumin, hemoglobin, log hs-CRP, obesity, and metabolic syndrome. CONCLUSIONS: Serum leptin may represent a novel serum biomarker for diagnosis of CKD, in addition to other many traditional risk factors.
KW - chronic kidney disease
KW - community
KW - leptin
KW - metabolic syndrome
KW - obesity
U2 - 10.6221/AN.202103_35(1).0003
DO - 10.6221/AN.202103_35(1).0003
M3 - Article
SN - 1013-1671
VL - 35
SP - 15
EP - 26
JO - Acta Nephrologica
JF - Acta Nephrologica
IS - 1
ER -
