High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

Cheng Huang Shen; Hsiao Yen Hsieh; Yuan Hung Wang; Syue Yi Chen; Chun Liang Tung; Jiann Der Wu; Chang Te Lin Lin; Michael W.Y. Chan; Cheng Da Hsu; Deching Chang

doi:10.3892/etm.2010.134

High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

Cheng Huang Shen, Hsiao Yen Hsieh, Yuan Hung Wang, Syue Yi Chen, Chun Liang Tung, Jiann Der Wu, Chang Te Lin Lin, Michael W.Y. Chan, Cheng Da Hsu, Deching Chang

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UCprogression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UCtissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. Ahigh-serum DKK1 was also associated with poor disease-free survival in the UCpatients (hazard ratio=2.44; 95% CI1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UCprogression.

Original language	English
Pages (from-to)	893-898
Number of pages	6
Journal	Experimental and Therapeutic Medicine
Volume	1
Issue number	5
DOIs	https://doi.org/10.3892/etm.2010.134
Publication status	Published - Sept 2010

Keywords

Dickkopf-1
Disease-free survival
Urothelial carcinoma

ASJC Scopus subject areas

Immunology and Microbiology (miscellaneous)
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/etm.2010.134

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title = "High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma",

abstract = "Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UCprogression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UCtissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. Ahigh-serum DKK1 was also associated with poor disease-free survival in the UCpatients (hazard ratio=2.44; 95% CI1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UCprogression.",

keywords = "Dickkopf-1, Disease-free survival, Urothelial carcinoma",

author = "Shen, {Cheng Huang} and Hsieh, {Hsiao Yen} and Wang, {Yuan Hung} and Chen, {Syue Yi} and Tung, {Chun Liang} and Wu, {Jiann Der} and Lin, {Chang Te Lin} and Chan, {Michael W.Y.} and Hsu, {Cheng Da} and Deching Chang",

year = "2010",

month = sep,

doi = "10.3892/etm.2010.134",

language = "English",

volume = "1",

pages = "893--898",

journal = "Experimental and Therapeutic Medicine",

issn = "1792-0981",

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T1 - High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

AU - Shen, Cheng Huang

AU - Hsieh, Hsiao Yen

AU - Wang, Yuan Hung

AU - Chen, Syue Yi

AU - Tung, Chun Liang

AU - Wu, Jiann Der

AU - Lin, Chang Te Lin

AU - Chan, Michael W.Y.

AU - Hsu, Cheng Da

AU - Chang, Deching

PY - 2010/9

Y1 - 2010/9

N2 - Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UCprogression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UCtissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. Ahigh-serum DKK1 was also associated with poor disease-free survival in the UCpatients (hazard ratio=2.44; 95% CI1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UCprogression.

AB - Although Dickkopf-1 (DKK1) has been demonstrated to be associated with tumorigenesis in various types of human tumors, a correlation between DKK1 and urothelial carcinoma (UC) has not been reported. In the present study, the correlation between DKK1 expression and UCprogression was investigated. Seventy-five UC patients were enrolled. The expression of DKK1 in serum and UCtissue was detected by ELISA, real-time PCR and Western blotting. Prognostic significance was assessed by using Kaplan-Meier survival estimates and log-rank tests. The results showed that serum levels of DKK1 were significantly higher in the UC patients with muscle-invasive (p=0.0001) and high-grade tumors (p=0.00001) as compared to the controls. Ahigh-serum DKK1 was also associated with poor disease-free survival in the UCpatients (hazard ratio=2.44; 95% CI1.10-5.40; p=0.028). Furthermore, DKK1 was also overexpressed in 93% (41/44) of the UC tissues. Therefore, the findings indicate that the expression of DKK1 is associated with UCprogression.

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KW - Disease-free survival

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High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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