High-density lipoprotein prevents organ damage in endotoxemia

Ru Ping Lee; Nien Tsung Lin; Yann Fen Chiou Chao; Chia-Chin Lin; Horng Jyh Harn; Hsing I. Chen

doi:10.1002/nur.20187

High-density lipoprotein prevents organ damage in endotoxemia

Ru Ping Lee
, Nien Tsung Lin
, Yann Fen Chiou Chao
, Chia-Chin Lin
, Horng Jyh Harn
, Hsing I. Chen

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.

Original language	English
Pages (from-to)	250-260
Number of pages	11
Journal	Research in Nursing and Health
Volume	30
Issue number	3
DOIs	https://doi.org/10.1002/nur.20187
Publication status	Published - Jun 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animal model
Endotoxemia
Lipoprotein
Organ damage

ASJC Scopus subject areas

General Nursing

Access to Document

10.1002/nur.20187

Cite this

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title = "High-density lipoprotein prevents organ damage in endotoxemia",

abstract = "High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.",

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T1 - High-density lipoprotein prevents organ damage in endotoxemia

AU - Lee, Ru Ping

AU - Lin, Nien Tsung

AU - Chao, Yann Fen Chiou

AU - Lin, Chia-Chin

AU - Harn, Horng Jyh

AU - Chen, Hsing I.

PY - 2007/6

Y1 - 2007/6

N2 - High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.

AB - High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage.

KW - Animal model

KW - Endotoxemia

KW - Lipoprotein

KW - Organ damage

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UR - https://www.scopus.com/pages/publications/34250823480#tab=citedBy

U2 - 10.1002/nur.20187

DO - 10.1002/nur.20187

M3 - Article

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AN - SCOPUS:34250823480

SN - 0160-6891

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JO - Research in Nursing and Health

JF - Research in Nursing and Health

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ER -

High-density lipoprotein prevents organ damage in endotoxemia

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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