High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe

Chih Pin Tsai; Yann Hung; Yi Hsin Chou; Dong Ming Huang; Jong Kai Hsiao; Chen Chang; Yao Chang Chen; Chung Yuan Mou

doi:10.1002/smll.200700457

High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe

Chih Pin Tsai, Yann Hung, Yi Hsin Chou, Dong Ming Huang, Jong Kai Hsiao, Chen Chang, Yao Chang Chen, Chung Yuan Mou

Research output: Contribution to journal › Article › peer-review

191 Citations (Scopus)

Abstract

The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl ₃-6H₂O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.

Original language	English
Pages (from-to)	186-191
Number of pages	6
Journal	Small
Volume	4
Issue number	2
DOIs	https://doi.org/10.1002/smll.200700457
Publication status	Published - Feb 2008
Externally published	Yes

Keywords

Fluorescent probes
Imaging
Magnetic properties
Mesoporous materials
Nanorods

ASJC Scopus subject areas

Biotechnology
Biomaterials
General Chemistry
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.200700457

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abstract = "The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.",

keywords = "Fluorescent probes, Imaging, Magnetic properties, Mesoporous materials, Nanorods",

author = "Tsai, {Chih Pin} and Yann Hung and Chou, {Yi Hsin} and Huang, {Dong Ming} and Hsiao, {Jong Kai} and Chen Chang and Chen, {Yao Chang} and Mou, {Chung Yuan}",

year = "2008",

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doi = "10.1002/smll.200700457",

language = "English",

volume = "4",

pages = "186--191",

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AU - Tsai, Chih Pin

AU - Hung, Yann

AU - Chou, Yi Hsin

AU - Huang, Dong Ming

AU - Hsiao, Jong Kai

AU - Chang, Chen

AU - Chen, Yao Chang

AU - Mou, Chung Yuan

PY - 2008/2

Y1 - 2008/2

N2 - The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.

AB - The development of a new multifunctional mesoporous silica nanorod that features green fluorescence and paramagnetism, is analyzed. The multifunctional nanorods were synthesized by surfactant-templated self-assembly, which can be used as a contrast agent in magnetic resonance imaging (MRI). These nanorods were washed with water and ethanol and heated at 60°C for 24 h to remove the surfactant. The surfactant-free nanorods, Dye@MSN-R, were mixed with GdCl 3-6H2O in 75% aqueous methanol and stirred at 40°C for 18 h to form the multifuctional nanorods Gd-Dye@MSN-R. The morphology and size distribution of Gd-Dye@MSN-R were examined by transmission electron microscopy (TEM). The bifunctional properties of nanorods were also analyzed to use as a cell marker. Results show that nanorods exhibit potential in monitoring cell trafficking and cancer cell metastasis, and drug/DNA delivery effectively.

KW - Fluorescent probes

KW - Imaging

KW - Magnetic properties

KW - Mesoporous materials

KW - Nanorods

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High-contrast paramagnetic fluorescent mesoporous silica nanorods as a multifunctional cell-imaging probe

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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