High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

Etienne Simon-Loriere; Ren-Jye Lin; Sita Mint Kalayanarooj; Ampaiwan Chuansumrit; Isabelle Casademont; Shyr Yi Lin; Han Pang Yu; Worachart Lert-Itthiporn; Wathanee Chaiyaratana; Nattaya Tangthawornchaikul; Kanchana Tangnararatchakit; Sirijitt Vasanawathana; Bi Lan Chang; Prapat Suriyaphol; Sutee Yoksan; Prida Malasit; Philipe Despres; Richard Paul; Yi Ling Lin; Anavaj Sakuntabhai

doi:10.1093/infdis/jiv321

High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

Etienne Simon-Loriere
, Ren-Jye Lin
, Sita Mint Kalayanarooj
, Ampaiwan Chuansumrit
, Isabelle Casademont
, Shyr Yi Lin
, Han Pang Yu
, Worachart Lert-Itthiporn
, Wathanee Chaiyaratana
, Nattaya Tangthawornchaikul
, Kanchana Tangnararatchakit
, Sirijitt Vasanawathana
, Bi Lan Chang
, Prapat Suriyaphol
, Sutee Yoksan
, Prida Malasit
, Philipe Despres
, Richard Paul
, Yi Ling Lin
, Anavaj Sakuntabhai

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P

Original language	English
Pages (from-to)	2011-2020
Number of pages	10
Journal	Journal of Infectious Diseases
Volume	212
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiv321
Publication status	Published - Dec 15 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytokine storm
Dengue virus
Genetic susceptibility
Innate immunity
Interferon

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiv321

Cite this

Simon-Loriere, E., Lin, R.-J., Kalayanarooj, S. M., Chuansumrit, A., Casademont, I., Lin, S. Y., Yu, H. P., Lert-Itthiporn, W., Chaiyaratana, W., Tangthawornchaikul, N., Tangnararatchakit, K., Vasanawathana, S., Chang, B. L., Suriyaphol, P., Yoksan, S., Malasit, P., Despres, P., Paul, R., Lin, Y. L., & Sakuntabhai, A. (2015). High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue. Journal of Infectious Diseases, 212(12), 2011-2020. https://doi.org/10.1093/infdis/jiv321

Simon-Loriere, E, Lin, R-J, Kalayanarooj, SM, Chuansumrit, A, Casademont, I, Lin, SY, Yu, HP, Lert-Itthiporn, W, Chaiyaratana, W, Tangthawornchaikul, N, Tangnararatchakit, K, Vasanawathana, S, Chang, BL, Suriyaphol, P, Yoksan, S, Malasit, P, Despres, P, Paul, R, Lin, YL & Sakuntabhai, A 2015, 'High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue', Journal of Infectious Diseases, vol. 212, no. 12, pp. 2011-2020. https://doi.org/10.1093/infdis/jiv321

@article{ed1cdc0ad8e247dba32a2f5ad01f36ce,

title = "High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue",

abstract = "Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P ",

keywords = "Cytokine storm, Dengue virus, Genetic susceptibility, Innate immunity, Interferon",

author = "Etienne Simon-Loriere and Ren-Jye Lin and Kalayanarooj, \{Sita Mint\} and Ampaiwan Chuansumrit and Isabelle Casademont and Lin, \{Shyr Yi\} and Yu, \{Han Pang\} and Worachart Lert-Itthiporn and Wathanee Chaiyaratana and Nattaya Tangthawornchaikul and Kanchana Tangnararatchakit and Sirijitt Vasanawathana and Chang, \{Bi Lan\} and Prapat Suriyaphol and Sutee Yoksan and Prida Malasit and Philipe Despres and Richard Paul and Lin, \{Yi Ling\} and Anavaj Sakuntabhai",

note = "Publisher Copyright: {\textcopyright} 2015 The Author.",

year = "2015",

month = dec,

day = "15",

doi = "10.1093/infdis/jiv321",

language = "English",

volume = "212",

pages = "2011--2020",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

AU - Simon-Loriere, Etienne

AU - Lin, Ren-Jye

AU - Kalayanarooj, Sita Mint

AU - Chuansumrit, Ampaiwan

AU - Casademont, Isabelle

AU - Lin, Shyr Yi

AU - Yu, Han Pang

AU - Lert-Itthiporn, Worachart

AU - Chaiyaratana, Wathanee

AU - Tangthawornchaikul, Nattaya

AU - Tangnararatchakit, Kanchana

AU - Vasanawathana, Sirijitt

AU - Chang, Bi Lan

AU - Suriyaphol, Prapat

AU - Yoksan, Sutee

AU - Malasit, Prida

AU - Despres, Philipe

AU - Paul, Richard

AU - Lin, Yi Ling

AU - Sakuntabhai, Anavaj

PY - 2015/12/15

Y1 - 2015/12/15

N2 - Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P

AB - Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti- DENV-1 activity. Conversely, whereas both OAS3-S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3-S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3-R381 against shock (odds ratio [OR], 0.37; P

KW - Cytokine storm

KW - Dengue virus

KW - Genetic susceptibility

KW - Innate immunity

KW - Interferon

UR - https://www.scopus.com/pages/publications/84954092943

UR - https://www.scopus.com/pages/publications/84954092943#tab=citedBy

U2 - 10.1093/infdis/jiv321

DO - 10.1093/infdis/jiv321

M3 - Article

C2 - 26063222

AN - SCOPUS:84954092943

SN - 0022-1899

VL - 212

SP - 2011

EP - 2020

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 12

ER -

High anti-dengue virus activity of the OAS gene family is associated with increased severity of dengue

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this