Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin, Jung Sun Kim, Sai Peng Sim, Angela Liu, Daniel S. Pilch, Leroy-Fong Liu, Edmond J. Lavoie

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)719-723
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number8
Publication statusPublished - Apr 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science


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