Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin; Jung Sun Kim; Sai Peng Sim; Angela Liu; Daniel S. Pilch; Leroy-Fong Liu; Edmond J. Lavoie

doi:10.1016/S0960-894X(00)00087-1

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin, Jung Sun Kim, Sai Peng Sim, Angela Liu, Daniel S. Pilch, Leroy-Fong Liu, Edmond J. Lavoie

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	719-723
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(00)00087-1
Publication status	Published - Apr 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/S0960-894X(00)00087-1

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abstract = "A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.",

author = "Song Jin and Kim, {Jung Sun} and Sim, {Sai Peng} and Angela Liu and Pilch, {Daniel S.} and Leroy-Fong Liu and Lavoie, {Edmond J.}",

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AU - Jin, Song

AU - Kim, Jung Sun

AU - Sim, Sai Peng

AU - Liu, Angela

AU - Pilch, Daniel S.

AU - Liu, Leroy-Fong

AU - Lavoie, Edmond J.

PY - 2000/4

Y1 - 2000/4

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AB - A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

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IS - 8

ER -

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Abstract

ASJC Scopus subject areas

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