Herniated blastomere following chemically assisted hatching may result in monozygotic twins

Tzong Chyi Sheen; Su Ru Chen; Heng Kien Au; Yi Yi Chien; Ko Yi Wu; Chii Ruey Tzeng

doi:10.1016/S0015-0282(00)01710-6

Herniated blastomere following chemically assisted hatching may result in monozygotic twins

Tzong Chyi Sheen, Su Ru Chen, Heng Kien Au, Yi Yi Chien, Ko Yi Wu, Chii Ruey Tzeng

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

Original language	English
Pages (from-to)	442-444
Number of pages	3
Journal	Fertility and Sterility
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/S0015-0282(00)01710-6
Publication status	Published - 2001

Keywords

Assisted hatching
Blastomere herniation
Monozygotic twins

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology

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10.1016/S0015-0282(00)01710-6

Cite this

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title = "Herniated blastomere following chemically assisted hatching may result in monozygotic twins",

abstract = "Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.",

keywords = "Assisted hatching, Blastomere herniation, Monozygotic twins",

author = "Sheen, {Tzong Chyi} and Chen, {Su Ru} and Au, {Heng Kien} and Chien, {Yi Yi} and Wu, {Ko Yi} and Tzeng, {Chii Ruey}",

year = "2001",

doi = "10.1016/S0015-0282(00)01710-6",

language = "English",

volume = "75",

pages = "442--444",

journal = "Fertility and Sterility",

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T1 - Herniated blastomere following chemically assisted hatching may result in monozygotic twins

AU - Sheen, Tzong Chyi

AU - Chen, Su Ru

AU - Au, Heng Kien

AU - Chien, Yi Yi

AU - Wu, Ko Yi

AU - Tzeng, Chii Ruey

PY - 2001

Y1 - 2001

N2 - Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

AB - Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

KW - Assisted hatching

KW - Blastomere herniation

KW - Monozygotic twins

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JO - Fertility and Sterility

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IS - 2

ER -

Herniated blastomere following chemically assisted hatching may result in monozygotic twins

Abstract

Keywords

ASJC Scopus subject areas

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