Herniated blastomere following chemically assisted hatching may result in monozygotic twins

Tzong Chyi Sheen, Su Ru Chen, Heng Kien Au, Yi Yi Chien, Ko Yi Wu, Chii Ruey Tzeng

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Objective: To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos. Design: Case report. Setting: Clinical research center in a medical school teaching hospital. Patient(s): A 37-year-old infertile woman with repeated IVF failures. Intervention(s): Assisted hatching of the day 3 embryos using acidic Tyrode's solution. Main Outcome Measure(s): The morphology of the zona-drilled embryos and the pregnancy outcome. Result(s): After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy. Conclusion(s): Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalFertility and Sterility
Issue number2
Publication statusPublished - 2001


  • Assisted hatching
  • Blastomere herniation
  • Monozygotic twins

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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