Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers

Yu Chen S.H. Yang, Zi Lin Li, Ya Jung Shih, James A. Bennett, Jaqueline Whang-Peng, Hung Yun Lin, Paul J. Davis, Kuan Wang

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Pro-inflammatory hormones and cytokines (leptin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6) rise in obesity. Elevated levels of hormones and cytokines are linked with several comorbidities such as diabetes, heart disease, and cancer. The checkpoint programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) plays an important role in obesity and cancer proliferation. L-thyroxine (T4) and steroid hormones up-regulate PD-L1 accumulation and promote inflammation in cancer cells and diabetics. On the other hand, resveratrol and other herbal medicines suppress PD-L1 accumulation and reduce diabetic effects. In addition, they induce anti-cancer proliferation in various types of cancer cells via different mechanisms. In the current review, we discuss new findings and visions into the antagonizing effects of hormones on herbal medicine-induced anti-cancer properties.

Original languageEnglish
Article number2979
Issue number12
Publication statusPublished - Dec 2019


  • Anoectochilus formosanus hayata
  • Curcumin
  • PD-L1
  • Resveratrol
  • Steroid hormone
  • Thyroid hormone

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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