TY - JOUR
T1 - Hepatoprotective effects of arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage
AU - Lin, Song-Chow
AU - Chung, Tsao-Chuen
AU - Lin, Chun Ching
AU - Ueng, Tzuu Huei
AU - Lin, Yun Ho
AU - Lin, Shuw Yuan
AU - Wang, Li Ya
PY - 2000
Y1 - 2000
N2 - The root ofArctium lappa Linné (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride (CCl4,32 μl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). A. lappa suppressed the SCOT and SGPT elevations induced by CC 14 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen.
AB - The root ofArctium lappa Linné (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride (CCl4,32 μl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). A. lappa suppressed the SCOT and SGPT elevations induced by CC 14 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen.
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U2 - 10.1142/S0192415X00000210
DO - 10.1142/S0192415X00000210
M3 - Article
C2 - 10999435
AN - SCOPUS:0033647831
SN - 0192-415X
VL - 28
SP - 163
EP - 173
JO - American Journal of Chinese Medicine
JF - American Journal of Chinese Medicine
IS - 2
ER -