Hepatitis C virus infection in patients with primary biliary cirrhosis

Hsuan-Wei Chen, Hsin-Hung Huang, Ching-Huang Lai, Wei-En Chang, Yu-Lueng Shih, Wei-Kuo Chang, Tsai-Yuan Hsieh, Heng-Cheng Chu

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9 Citations (Scopus)


Background and aim. The aim of this study is to evaluate the role of hepatitis C virus (HCV) infection in patients with primary biliary cirrhosis (PBC). Material and methods. On the basis of a retrospective review of medical records, all patients consecutively diagnosed with PBC or HCV infection between 1999 and 2011 and who had a regular follow-up of at least 3 years were included in the study. Clinical characteristics, especially the severity of cirrhosis, were analyzed in PBC patients with HCV infection (PBC-HCV), PBC patients without HCV infection (PBC-only), and patients with only HCV infection (HCV-only). Results. A total of 76 patients with PBC, including 9 patients with HCV infection, were analyzed. Of the PBC-HCV patients, 7 (7/9, 77.8%) were women with a mean age of 55.11 ± 14.29 years. Age- and sex-matched PBC-only patients (n = 36) and HCV-only patients (n = 36) were used as control groups. In comparison to the PBC-only controls, PBC-HCV patients had a greater severity of cirrhosis based on Child-Pugh (p = 0.019) and Model for End-Stage Liver Disease (MELD) (p = 0.01) scores. However, no significant difference in the severity of cirrhosis was found between the PBC-HCV and HCV-only control patients (p = 0.94 in Child-Pugh scores; p = 0.64 in MELD scores). Conclusions. In PBC patients with concomitant HCV infection, aggressive management may be warranted in view of the associated more severe liver cirrhosis.
Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalAnnals of Hepatology
Issue number1
Publication statusPublished - 2013
Externally publishedYes


  • Child-Pugh score
  • Cirrhosis
  • MELD score
  • alanine aminotransferase
  • albumin
  • aspartate aminotransferase
  • bilirubin
  • creatinine
  • interferon
  • ribavirin
  • virus RNA
  • adult
  • age
  • aged
  • article
  • ascites
  • autoimmune disease
  • bleeding
  • Child Pugh score
  • clinical article
  • comorbidity
  • controlled study
  • death
  • disease severity
  • female
  • follow up
  • hepatitis C
  • human
  • international normalized ratio
  • liver cell carcinoma
  • liver cirrhosis
  • male
  • medical record review
  • Model For End Stage Liver Disease Score
  • neoplasm
  • primary biliary cirrhosis
  • survival rate
  • virus load
  • biliary cirrhosis
  • case control study
  • disease course
  • middle aged
  • prognosis
  • retrospective study
  • severity of illness index
  • Adult
  • Aged
  • Case-Control Studies
  • Disease Progression
  • Female
  • Hepatitis C
  • Humans
  • Liver Cirrhosis, Biliary
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Severity of Illness Index


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