Hepatitis B virus infection and the risk of male infertility: A population-based analysis

Fu-Hsiung Su, Shih Ni Chang, Fung Chang Sung, Chien-Tien Su, Ying-Hua Shieh, Cheng Chieh Lin, Chih-Ching Yeh

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection. Design: A nationwide, population-based cohort study. Setting: Not applicable. Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690). Intervention(s): None. Main Outcome Measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model. Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

Original languageEnglish
Pages (from-to)1677-1684
Number of pages8
JournalFertility and Sterility
Issue number6
Publication statusPublished - Dec 1 2014


  • Hepatitis B virus
  • Male infertility
  • Population-based study

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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