Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan

Yu Hsuan Huang, Tzou Yien Lin, Kin Sun Wong, Yhu Chering Huang, Cheng Hsun Chiu, Shen Hao Lai, Shao Hsuan Hsia

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


Streptococcus pneumoniae (S. pneumoniae) has been associated with hemolytic uremic syndrome (HUS), which is an unusual but serious disease in childhood. We conducted a retrospective review of children aged less than 18 years with S. pneumoniae-associated HUS in northern Taiwan from January 2000 to June 2005. The demographic characters, clinical courses, and outcomes were analyzed. Seven children (three girls, four boys) with S. pneumoniae-associated HUS were studied. The median age at onset of HUS was 40 months (range: 25-60 months). The median duration of hospital stay was 36 days (range: 15-50 days). The interval between the onset of illness attributable to S. pneumoniae and the development of HUS was around 1-2 weeks. The onset of oliguria developed within 2 weeks after illness. Six patients required dialysis with median duration of 16 days. Three patients had leukopenia as the initial presentation. All seven patients had pneumococcal pneumonia complicating with empyema, and two of them received decortication via video-assisted thoracoscopic surgery. Between patients who needed dialysis or not, there was no significant difference in age, sex, duration of thrombocytopenia, incidence of extra-renal complications, such as hepatitis, pancreatitis, and hypertension, and length of hospital stay. The seven patients survived with normal renal function. HUS is a potentially fatal complication of S. pneumoniae infection. Clinicians managing patients with pneumococcal pneumonia with empyema accompanied by leukopenia should beware of the development of HUS. The long-term prognosis for recovery of renal function appears to be good in these patients in northern Taiwan.

Original languageEnglish
Pages (from-to)332-335
Number of pages4
JournalEuropean Journal of Pediatrics
Issue number5
Publication statusPublished - May 2006
Externally publishedYes


  • Hemolytic anemia
  • Hemolytic uremic syndrome
  • Renal failure
  • Streptococcus pneumoniae
  • Thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan'. Together they form a unique fingerprint.

Cite this