Hemolysis in double-filtration plasmapheresis

Jiann Horng Yeh; Wei Hung Chen; Hou Chang Chiu; Chyi Huey Bai

doi:10.1309/F8XMTALTTCE5H37U

Hemolysis in double-filtration plasmapheresis

Jiann Horng Yeh, Wei Hung Chen, Hou Chang Chiu, Chyi Huey Bai

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

Original language	English
Pages (from-to)	76-80
Number of pages	5
Journal	American Journal of Clinical Pathology
Volume	127
Issue number	1
DOIs	https://doi.org/10.1309/F8XMTALTTCE5H37U
Publication status	Published - Jan 2007
Externally published	Yes

Keywords

Double-filtration plasmapheresis
Hemolysis
Heparin
Transmembrane pressure
Vascular access

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/F8XMTALTTCE5H37U

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title = "Hemolysis in double-filtration plasmapheresis",

abstract = "To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.",

keywords = "Double-filtration plasmapheresis, Hemolysis, Heparin, Transmembrane pressure, Vascular access",

author = "Yeh, {Jiann Horng} and Chen, {Wei Hung} and Chiu, {Hou Chang} and Bai, {Chyi Huey}",

year = "2007",

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doi = "10.1309/F8XMTALTTCE5H37U",

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AU - Yeh, Jiann Horng

AU - Chen, Wei Hung

AU - Chiu, Hou Chang

AU - Bai, Chyi Huey

PY - 2007/1

Y1 - 2007/1

N2 - To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

AB - To evaluate the occurrence of hemolysis during double-filtration plasmapheresis (DFP) treatment and its causes, we prospectively treated 113 myasthenic patients and monitored transmembrane pressure (TMP), arterial line pressure (Pa), and venous line pressure (Pv) at 30-minute intervals (M30, M60, M90, and M120) during treatment. Laboratory and clinical parameters related to the development of hemolysis were also analyzed. The overall frequency of hemolysis was 35.4%. Peripheral venous access was associated with a higher rate of hemolysis (45.3%). The mean TMP increased significantly after M30 for the hemolysis group compared with the no hemolysis group. A similar trend was present for Pa. Pv did not differ between the 2 groups during treatments until M90 and M120. Pa and TMP changed significantly with time (both P <.0001). Vascular access through large veins and stable TMP during the procedure may help avoid hemolysis.

KW - Double-filtration plasmapheresis

KW - Hemolysis

KW - Heparin

KW - Transmembrane pressure

KW - Vascular access

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Hemolysis in double-filtration plasmapheresis

Abstract

Keywords

ASJC Scopus subject areas

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