TY - JOUR
T1 - Hemoglobin A1C levels are independently associated with the risk of coronary atherosclerotic plaques in patients without diabetes
T2 - A cross-sectional study
AU - Wang, Wei Ting
AU - Hsu, Pai Feng
AU - Lin, Chung Chi
AU - Wang, Yuan Jen
AU - Ding, Yaw Zon
AU - Liou, Teh Ling
AU - Wang, Ying Wen
AU - Huang, Shao Sung
AU - Lu, Tse Min
AU - Huang, Po Hsun
AU - Chen, Jaw Wen
AU - Chan, Wan Leong
AU - Lin, Shing Jong
AU - Leu, Hsin Bang
N1 - Publisher Copyright:
© 2020 Japan Atherosclerosis Society.
PY - 2020
Y1 - 2020
N2 - Aim: Coronary atherosclerotic plaques can be detected in asymptomatic subjects and are related to low-density lipoprotein cholesterol (LDL) levels in patients with coronary artery disease. However, researchers have not yet determined the associations between various plaque characteristics and other lipid parameters, such as HDL-C and TG levels, in low-risk populations. Methods: One thousand sixty-four non-diabetic subjects (age, 57.86±9.73 years; 752 males) who underwent coronary computed tomography angiography (CCTA) were enrolled and the severity and patterns of atheroscle-rotic plaques were analyzed. Results: Statin use was reported by 25% of the study population, and subjects with greater coronary plaque involvement (segment involvement score, SIS) were older and had a higher body mass index (BMI), blood pres-sure, unfavorable lipid profiles and comorbidities. After adjusting for comorbidities, only age (β=0.085, p＜ 0.001), the male gender (β=1.384, p＜0.001), BMI (β=0.055, p=0.019) and HbA1C levels (β=0.894, p＜ 0.001) were independent factors predicting the greater coronary plaque involvement in non-diabetic subjects. In the analysis of significantly different (＞50%) stenosis plaque patterns, age (OR: 1.082, 95% CI: 10.47-1.118) and a former smoking status (OR: 2.061, 95% CI: 1.013-4.193) were independently associated with calcified plaques. For partial calcified (mixed type) plaques, only age (OR: 1.085, 95% CI: 1.052-1.119), the male gender (OR: 7.082, 95% CI: 2.638-19.018), HbA1C levels (OR: 2.074, 95% CI: 1.036-4.151), and current smoking status (OR: 1.848, 95% CI: 1.089-3.138) were independently associated with the risk of the presence of significant stenosis in mixed plaques. Conclusions: A higher HbA1c levels is independently associated with the presence and severity of coronary artery atherosclerosis in non-diabetic subjects, even when LDL-C levels are tightly controlled.
AB - Aim: Coronary atherosclerotic plaques can be detected in asymptomatic subjects and are related to low-density lipoprotein cholesterol (LDL) levels in patients with coronary artery disease. However, researchers have not yet determined the associations between various plaque characteristics and other lipid parameters, such as HDL-C and TG levels, in low-risk populations. Methods: One thousand sixty-four non-diabetic subjects (age, 57.86±9.73 years; 752 males) who underwent coronary computed tomography angiography (CCTA) were enrolled and the severity and patterns of atheroscle-rotic plaques were analyzed. Results: Statin use was reported by 25% of the study population, and subjects with greater coronary plaque involvement (segment involvement score, SIS) were older and had a higher body mass index (BMI), blood pres-sure, unfavorable lipid profiles and comorbidities. After adjusting for comorbidities, only age (β=0.085, p＜ 0.001), the male gender (β=1.384, p＜0.001), BMI (β=0.055, p=0.019) and HbA1C levels (β=0.894, p＜ 0.001) were independent factors predicting the greater coronary plaque involvement in non-diabetic subjects. In the analysis of significantly different (＞50%) stenosis plaque patterns, age (OR: 1.082, 95% CI: 10.47-1.118) and a former smoking status (OR: 2.061, 95% CI: 1.013-4.193) were independently associated with calcified plaques. For partial calcified (mixed type) plaques, only age (OR: 1.085, 95% CI: 1.052-1.119), the male gender (OR: 7.082, 95% CI: 2.638-19.018), HbA1C levels (OR: 2.074, 95% CI: 1.036-4.151), and current smoking status (OR: 1.848, 95% CI: 1.089-3.138) were independently associated with the risk of the presence of significant stenosis in mixed plaques. Conclusions: A higher HbA1c levels is independently associated with the presence and severity of coronary artery atherosclerosis in non-diabetic subjects, even when LDL-C levels are tightly controlled.
KW - Atherosclerotic plaque
KW - Coronary computed tomography angiography
KW - High-density lipoprotein cholesterol
KW - Low-density lipoprotein cholesterol
KW - Non-diabetic
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U2 - 10.5551/jat.51425
DO - 10.5551/jat.51425
M3 - Article
C2 - 31902804
AN - SCOPUS:85088939532
SN - 1340-3478
VL - 27
SP - 789
EP - 800
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
IS - 8
ER -
