Hemodilution accelerates the passage of plasma (not red cells) through cerebral microvessels in rats

S. Z. Lin, T. L. Chiou, Y. H. Chiang, W. S. Song, J. C. LaManna

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background and Purpose: Hemodilution lowers the total circulatory red cell mass and blood viscosity and thereby may alter the time of passage of red cells and plasma through cerebral microvessels. This study was designed to clarify this question. Methods: Adult Wistar-Kyoto rats, aged approximately 32 weeks, were divided into hemodilution and control groups. Local cerebral blood flow and microvascular red cells and plasma volumes in 14 brain structures were measured with the use of [14C]iodoantipyrine. 55Fe- labeled red cells, and [14C]inulin, respectively. Results: In the control group, the hematocrit in cerebral microvessels ranged from 0.29 to 0.45 with a mean of 0.36, which was 71% of the systemic hematocrit (0.51). The mean transit times of blood, red cells, and plasma through microvessels were 0.62 to 1.77 seconds (mean, 0.92 second), 0.44 to 1.15 seconds (mean, 0.65 second), and 0.78 to 2.5 seconds (mean, 1.25 seconds), respectively. In the hemodilution group, the mean hematocrit in microvessels was 0.28, which was 89% of the systemic hematocrit (0.32). Local cerebral blood flow was approximately 59% higher (P

Original languageEnglish
Pages (from-to)2166-2171
Number of pages6
Issue number11
Publication statusPublished - 1995
Externally publishedYes


  • cerebral blood flow
  • cerebral blood volume
  • hemodilution
  • rats

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


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