TY - JOUR
T1 - Helicobacter pylori infection increases the risk of adult-onset asthma
T2 - a nationwide cohort study
AU - Wang, Y. C.
AU - Lin, T. Y.
AU - Shang, S. T.
AU - Chen, H. J.
AU - Kao, C. H.
AU - Wu, C. C.
AU - Yang, T. Y.
N1 - Funding Information:
Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan was supported in part by grants from the Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW106-TDU-B-212-113,004); China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037); NRPB Stroke Clinical Trial Consortium (MOST 105?2325-B-039-003); Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan Brain Disease Foundation, Taipei, Taiwan; and Katsuzo and Kiyo Aoshima Memorial Funds, Japan; And this study was also partly supported by Tri-Service General Hospital (TSGH-C104?117, TSGH-C105?112) and Armed Forces Tao-Yuan General Hospital (AFTYGH-10501, AFTYGH-10616). No additional external funding was received for this study. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Miss Hsuan-Ju Chen has received salary from Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan. Dr. Shih-Ta Shang was supported by the Armed Forces Tao-Yuan General Hospital (AFTYGH-10501, AFTYGH-10616); Dr. Yung-Chih Wang was supported by Tri-Service General Hospital (TSGH-C104?117, TSGH-C105?112). The other authors declare that they have no conflict of interest.
Funding Information:
Funding Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan was supported in part by grants from the Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence (MOHW106-TDU-B-212-113,004); China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10501010037); NRPB Stroke Clinical Trial Consortium (MOST 105–2325-B-039-003); Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan Brain Disease Foundation, Taipei, Taiwan; and Katsuzo and Kiyo Aoshima Memorial Funds, Japan; And this study was also partly supported by Tri-Service General Hospital (TSGH-C104–117, TSGH-C105–112) and Armed Forces Tao-Yuan General Hospital (AFTYGH-10501, AFTYGH-10616). No additional external funding was received for this study. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
Conflict of interest Miss Hsuan-Ju Chen has received salary from Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan. Dr. Shih-Ta Shang was supported by the Armed Forces Tao-Yuan General Hospital (AFTYGH-10501, AFTYGH-10616); Dr. Yung-Chih Wang was supported by Tri-Service General Hospital (TSGH-C104–117, TSGH-C105–112). The other authors declare that they have no conflict of interest.
Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Helicobacter pylori infection (HPI) appears to reduce risk of childhood-onset asthma, but the relationship between HPI and adult-onset asthma is inconclusive. This study explored the potential association between HPI and risk of adult-onset asthma. We conducted a national insurance retrospective cohort study using the longitudinal health insurance database (LHID 2000) in Taiwan. We enrolled the HPI group consisting of 1664 patients with HPI diagnosis between 2000 and 2007, and the non-HPI group consisting of 6,656 age- and sex-matched subjects without HPI. All study participants had been followed up from index date to the diagnostic date of asthma, withdrawal from the National Health Insurance program, or the end of 2011, which came first. We analyzed risk of adult-onset asthma with respect to sex, age, and comorbidities by using Cox models. Cigarette smoking status, which could not be obtained from the program, was adjusted indirectly by considering chronic obstructive pulmonary diseases in our statistical models because the disease is related to heavy smoking. After adjustment for sex, age, and comorbidities, HPI was significantly associated with an increased 1.38-fold risk of adult-onset asthma. Moreover, among people without comorbidities, the 1.85-fold risk of adult-onset asthma remained higher for the HPI population compared with the non-HPI population. In this study, patients with HPI exhibited a significantly higher risk of adult-onset asthma than did the subjects without HPI.
AB - Helicobacter pylori infection (HPI) appears to reduce risk of childhood-onset asthma, but the relationship between HPI and adult-onset asthma is inconclusive. This study explored the potential association between HPI and risk of adult-onset asthma. We conducted a national insurance retrospective cohort study using the longitudinal health insurance database (LHID 2000) in Taiwan. We enrolled the HPI group consisting of 1664 patients with HPI diagnosis between 2000 and 2007, and the non-HPI group consisting of 6,656 age- and sex-matched subjects without HPI. All study participants had been followed up from index date to the diagnostic date of asthma, withdrawal from the National Health Insurance program, or the end of 2011, which came first. We analyzed risk of adult-onset asthma with respect to sex, age, and comorbidities by using Cox models. Cigarette smoking status, which could not be obtained from the program, was adjusted indirectly by considering chronic obstructive pulmonary diseases in our statistical models because the disease is related to heavy smoking. After adjustment for sex, age, and comorbidities, HPI was significantly associated with an increased 1.38-fold risk of adult-onset asthma. Moreover, among people without comorbidities, the 1.85-fold risk of adult-onset asthma remained higher for the HPI population compared with the non-HPI population. In this study, patients with HPI exhibited a significantly higher risk of adult-onset asthma than did the subjects without HPI.
UR - http://www.scopus.com/inward/record.url?scp=85017149151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017149151&partnerID=8YFLogxK
U2 - 10.1007/s10096-017-2972-1
DO - 10.1007/s10096-017-2972-1
M3 - Article
AN - SCOPUS:85017149151
SN - 0934-9723
VL - 36
SP - 1587
EP - 1594
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 9
ER -
