TY - JOUR
T1 - Heart failure enhances arrhythmogenesis in pulmonary veins
AU - Chang, Shih Lin
AU - Chen, Yao Chang
AU - Yeh, Yung Hsin
AU - Lai, Yu Jun
AU - Yeh, Hung I.
AU - Lin, Cheng I.
AU - Lin, Yung Kuo
AU - Lin, Yenn Jiang
AU - Wu, Tsu Juey
AU - Huang, Yi Kung
AU - Chen, Shih Ann
AU - Chen, Yi Jen
PY - 2011/10
Y1 - 2011/10
N2 - 1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P<0.001) and high-frequency irregular electrical activity (92 vs 38%, P=0.01; 23±1 vs 19±1Hz, P=0.003), greater depolarized resting membrane potential (-59±1 vs -70±2mV, P<0.001), higher incidence of early afterdepolarizations (EAD; 69 vs 6%, P=0.001) and delayed afterdepolarizations (DAD; 92 vs 25%, P=0.001), and slower conduction velocity (38±2 vs 63±2cm/s, P<0.05). In comparison to the HF-LA, the HF-PV had a higher incidence of spontaneous activity and high-frequency irregular electrical activity (85 vs 39%, P=0.04; 92 vs 46%, P=0.03), and higher incidence of EAD and DAD, and those differences were not found between the control-LA and control-PV. The control-PV with high-frequency irregular electrical activity had a higher incidence of DAD and spontaneous activity as compared with those without it. 4.HF contributed to an increased automaticity, triggered activity and conduction disturbance in the PV. The PV possessed more arrhythmogenic properties, which might play an important role in the genesis of AF in HF.
AB - 1.Heart failure (HF) predisposes to atrial fibrillation (AF) as a result of substrate remodelling. The present study aimed to investigate the impact of HF on the electrical remodelling of the pulmonary veins (PV) and left atrium (LA). 2.The electrical activity was recorded in LA and PV from control rabbits and rabbits with rapid ventricular pacing-induced HF, using a multi-electrode array system and conventional microelectrodes. 3.Compared with the control-PV (n=21), the HF-PV (n=13) had a higher incidence and frequency of rapid pacing-induced spontaneous activity (85 vs 29%, P=0.005; 3.5±0.2 vs 1.7±0.1Hz, P<0.001) and high-frequency irregular electrical activity (92 vs 38%, P=0.01; 23±1 vs 19±1Hz, P=0.003), greater depolarized resting membrane potential (-59±1 vs -70±2mV, P<0.001), higher incidence of early afterdepolarizations (EAD; 69 vs 6%, P=0.001) and delayed afterdepolarizations (DAD; 92 vs 25%, P=0.001), and slower conduction velocity (38±2 vs 63±2cm/s, P<0.05). In comparison to the HF-LA, the HF-PV had a higher incidence of spontaneous activity and high-frequency irregular electrical activity (85 vs 39%, P=0.04; 92 vs 46%, P=0.03), and higher incidence of EAD and DAD, and those differences were not found between the control-LA and control-PV. The control-PV with high-frequency irregular electrical activity had a higher incidence of DAD and spontaneous activity as compared with those without it. 4.HF contributed to an increased automaticity, triggered activity and conduction disturbance in the PV. The PV possessed more arrhythmogenic properties, which might play an important role in the genesis of AF in HF.
KW - Multi-electrode
KW - Remodelling
KW - Triggered activity
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U2 - 10.1111/j.1440-1681.2011.05553.x
DO - 10.1111/j.1440-1681.2011.05553.x
M3 - Article
C2 - 21671985
AN - SCOPUS:80053169710
SN - 0305-1870
VL - 38
SP - 666
EP - 674
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 10
ER -