Health-related quality of life among patients with moderate-to-severe plaque psoriasis in Taiwan

Tsen Fang Tsai, Ji Chen Ho, Yi Ju Chen, Pa Fan Hsiao, Woan Ruoh Lee, Ching Chi Chi, Cheng Che Lan, Rosaline Chung Yee Hui, Yang Chih Lin, Kuo Chia Yang, Tak Wah Wong, Hamm Ming Sheu, Hsiu Cheng Hsu, Gong Yau Chu, Yu Huei Huang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background/Objectives: Plaque psoriasis is a debilitating condition that significantly affects patient well-being. Limited data are available regarding the effect of psoriasis and treatment on health-related quality of life (HRQoL) and work ability among Taiwanese patients. To document and compare HRQoL, treatment satisfaction, and work disability among Taiwanese patients with current and past moderate-to-severe plaque psoriasis. Methods: This was a multicenter, non-interventional, cross-sectional study of adult patients with moderate-to-severe plaque psoriasis. During a single clinic visit, each patient was assessed for body surface area (BSA) involvement, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), Euro Quality of Life-5 Dimensions (EQ-5D), 10-level satisfaction scale for psoriasis treatment, and Working Productivity and Activity Impairment (WPAI). Multivariate regression was used to identify factors associated with HRQoL and work disability. Results: A total of 305 patients were included within the analysis. The mean PASI score was 11.83, and the mean BSA involvement was 20.90%. The mean EQ-5D score was 65.68 and the mean DLQI score was 12.55. Fewer than half of patients (45.68%) indicated they were satisfied with the standard therapy they were currently receiving. Among employed patients, the mean reduction in on-the-job effectiveness was 32.09% and the mean reduction in overall productivity was 33.48%. The regression analysis indicated that patients with more severe psoriasis defined by PASI scores show a greater impact in quality of life and impairment in work disability; and that patients who were satisfied with current standard treatment had a better quality of life. Conclusion: The effect of psoriasis on HRQoL among patients with psoriasis in Taiwan is substantial, with fewer than half of patients reporting satisfaction with therapeutic options.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalDermatologica Sinica
Issue number4
Publication statusPublished - Dec 1 2018


  • DLQI
  • EQ-5D
  • Health-related quality of life
  • Psoriasis
  • WPAI

ASJC Scopus subject areas

  • Dermatology


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