GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh

Ema G. Rodrigues; Molly Kile; Elaine Hoffman; Quazi Quamruzzaman; Mahmuder Rahman; Golam Mahiuddin; Yumei Hsueh; David C. Christiani

doi:10.3109/1354750X.2012.658863

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh

Ema G. Rodrigues, Molly Kile, Elaine Hoffman, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Yumei Hsueh, David C. Christiani

Department of Public Health

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of As^III and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.

Original language	English
Pages (from-to)	240-247
Number of pages	8
Journal	Biomarkers
Volume	17
Issue number	3
DOIs	https://doi.org/10.3109/1354750X.2012.658863
Publication status	Published - May 2012

Keywords

Arsenic metabolism
Drinking water
Pathway analysis

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2012.658863

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title = "GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh",

abstract = "We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of AsIII and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.",

keywords = "Arsenic metabolism, Drinking water, Pathway analysis",

author = "Rodrigues, {Ema G.} and Molly Kile and Elaine Hoffman and Quazi Quamruzzaman and Mahmuder Rahman and Golam Mahiuddin and Yumei Hsueh and Christiani, {David C.}",

note = "Funding Information: This work was supported by the United States National Institute of Health grant T32 ES07069 and National Institute of Environmental Health Sciences grants # ES R01011622, ES P42016454, and ES 00002.",

year = "2012",

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doi = "10.3109/1354750X.2012.658863",

language = "English",

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journal = "Biomarkers",

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AU - Rodrigues, Ema G.

AU - Kile, Molly

AU - Hoffman, Elaine

AU - Quamruzzaman, Quazi

AU - Rahman, Mahmuder

AU - Mahiuddin, Golam

AU - Hsueh, Yumei

AU - Christiani, David C.

N1 - Funding Information: This work was supported by the United States National Institute of Health grant T32 ES07069 and National Institute of Environmental Health Sciences grants # ES R01011622, ES P42016454, and ES 00002.

PY - 2012/5

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N2 - We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of AsIII and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.

AB - We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of AsIII and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.

KW - Arsenic metabolism

KW - Drinking water

KW - Pathway analysis

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SN - 1354-750X

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JO - Biomarkers

JF - Biomarkers

IS - 3

ER -

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh

Abstract

Keywords

ASJC Scopus subject areas

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