Gross hematuria and IgA nephropathy flare-up following the first dose of Moderna vaccine A case report

Po Hung Tseng; Shu Han Chuang; Yueh Pan; Hung Jen Shih; Chin Pao Chang; Sheng Hsien Huang

doi:10.1097/MD.0000000000032524

Gross hematuria and IgA nephropathy flare-up following the first dose of Moderna vaccine A case report

Po Hung Tseng, Shu Han Chuang, Yueh Pan, Hung Jen Shih, Chin Pao Chang, Sheng Hsien Huang

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background: Since the mass vaccination for COVID-19, several case reports indicated the risk of autoimmune disease flareups after the vaccination. Among them, COVID-19 vaccine-induced glomerular diseases have drawn attention worldwide. The cases demonstrating the association between the mRNA vaccine and IgA nephropathy (IgAN) exacerbation had been noticed. Mostly mentioned, the flare-ups usually occurred after the second dose. Methods: We present a Taiwanese female with IgAN who developed gross hematuria within only six hours after the first dose of the Moderna vaccine. Results: Six hours after the first dose of Moderna vaccine on 8 June 2021, the patient developed gross hematuria and significantly decreased urine output. All symptoms resolved spontaneously on the fifth day after the vaccination without any intervention. On the fourth day after the vaccination, the patient were able to back to her original condition. Conclusion: This was an intriguing case of IgAN flare-up following the first dose of mRNA-based COVID-19 vaccination.

Original language	English
Article number	e32524
Journal	Medicine (United States)
Volume	101
Issue number	52
DOIs	https://doi.org/10.1097/MD.0000000000032524
Publication status	Published - Dec 2022

Keywords

COVID-19 mRNA vaccine
hematuria
IgA nephropathy
Moderna vaccine

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/MD.0000000000032524

Cite this

@article{7d3543165f0b4200a4612f76fda6c939,

title = "Gross hematuria and IgA nephropathy flare-up following the first dose of Moderna vaccine A case report",

abstract = "Background: Since the mass vaccination for COVID-19, several case reports indicated the risk of autoimmune disease flareups after the vaccination. Among them, COVID-19 vaccine-induced glomerular diseases have drawn attention worldwide. The cases demonstrating the association between the mRNA vaccine and IgA nephropathy (IgAN) exacerbation had been noticed. Mostly mentioned, the flare-ups usually occurred after the second dose. Methods: We present a Taiwanese female with IgAN who developed gross hematuria within only six hours after the first dose of the Moderna vaccine. Results: Six hours after the first dose of Moderna vaccine on 8 June 2021, the patient developed gross hematuria and significantly decreased urine output. All symptoms resolved spontaneously on the fifth day after the vaccination without any intervention. On the fourth day after the vaccination, the patient were able to back to her original condition. Conclusion: This was an intriguing case of IgAN flare-up following the first dose of mRNA-based COVID-19 vaccination.",

keywords = "COVID-19 mRNA vaccine, hematuria, IgA nephropathy, Moderna vaccine",

author = "Tseng, {Po Hung} and Chuang, {Shu Han} and Yueh Pan and Shih, {Hung Jen} and Chang, {Chin Pao} and Huang, {Sheng Hsien}",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 the Author(s). Published by Wolters Kluwer Health, Inc.",

year = "2022",

month = dec,

doi = "10.1097/MD.0000000000032524",

language = "English",

volume = "101",

journal = "Medicine (United States)",

issn = "0025-7974",

publisher = "Lippincott Williams and Wilkins",

number = "52",

}

TY - JOUR

T1 - Gross hematuria and IgA nephropathy flare-up following the first dose of Moderna vaccine A case report

AU - Tseng, Po Hung

AU - Chuang, Shu Han

AU - Pan, Yueh

AU - Shih, Hung Jen

AU - Chang, Chin Pao

AU - Huang, Sheng Hsien

PY - 2022/12

Y1 - 2022/12

N2 - Background: Since the mass vaccination for COVID-19, several case reports indicated the risk of autoimmune disease flareups after the vaccination. Among them, COVID-19 vaccine-induced glomerular diseases have drawn attention worldwide. The cases demonstrating the association between the mRNA vaccine and IgA nephropathy (IgAN) exacerbation had been noticed. Mostly mentioned, the flare-ups usually occurred after the second dose. Methods: We present a Taiwanese female with IgAN who developed gross hematuria within only six hours after the first dose of the Moderna vaccine. Results: Six hours after the first dose of Moderna vaccine on 8 June 2021, the patient developed gross hematuria and significantly decreased urine output. All symptoms resolved spontaneously on the fifth day after the vaccination without any intervention. On the fourth day after the vaccination, the patient were able to back to her original condition. Conclusion: This was an intriguing case of IgAN flare-up following the first dose of mRNA-based COVID-19 vaccination.

AB - Background: Since the mass vaccination for COVID-19, several case reports indicated the risk of autoimmune disease flareups after the vaccination. Among them, COVID-19 vaccine-induced glomerular diseases have drawn attention worldwide. The cases demonstrating the association between the mRNA vaccine and IgA nephropathy (IgAN) exacerbation had been noticed. Mostly mentioned, the flare-ups usually occurred after the second dose. Methods: We present a Taiwanese female with IgAN who developed gross hematuria within only six hours after the first dose of the Moderna vaccine. Results: Six hours after the first dose of Moderna vaccine on 8 June 2021, the patient developed gross hematuria and significantly decreased urine output. All symptoms resolved spontaneously on the fifth day after the vaccination without any intervention. On the fourth day after the vaccination, the patient were able to back to her original condition. Conclusion: This was an intriguing case of IgAN flare-up following the first dose of mRNA-based COVID-19 vaccination.

KW - COVID-19 mRNA vaccine

KW - hematuria

KW - IgA nephropathy

KW - Moderna vaccine

UR - http://www.scopus.com/inward/record.url?scp=85145428685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85145428685&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000032524

DO - 10.1097/MD.0000000000032524

M3 - Article

C2 - 36595987

AN - SCOPUS:85145428685

SN - 0025-7974

VL - 101

JO - Medicine (United States)

JF - Medicine (United States)

IS - 52

M1 - e32524

ER -

Gross hematuria and IgA nephropathy flare-up following the first dose of Moderna vaccine A case report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this