Glypican-3 Expression in Breast Cancer

Ching-Hua Tsai, Wei-Ti Su, Shyr-Ming Sheen-Chen, Jiun-Lung Liang, Hsien-Wen Hsu, Wei-Ting Chen, Eng-Yen Huang, Chao-Cheng Huang, Kung-Ming Rau, Rei-Ping Tang

Research output: Contribution to journalArticlepeer-review


Background: The protein Glypican-3 has been found in various types of tumors and has shown promise as a tumor marker. However, there is still very limited information about the role of Glypican-3 in breast cancer. Tissue microarray (TMA) analyzes thousands of specimens in parallel with minimal damage to the origin blocks. The purpose of this study was to ascertain the role of Glypican-3 status in breast cancer using TMA. Materials and Methods: Archival tissue specimens from 99 patients with primary invasive breast cancer were analyzed for Glypican-3 expression by immunohistochemical staining with TMA. The results were compared to clinicopathologic data by the use of multivariate analysis. Results: TNM stage was significantly related to the overall 5-year survival rate. Nevertheless, Glypican-3 expression has no significant relationship to overall five-year survival. Conclusions: Immunohistochemical staining with TMA was convenient and feasible for analyzing Glypican-3 expression status in breast cancer. However, our preliminary results show that Glypican-3 expression had no significant prognostic value in breast cancer.
Original languageEnglish
Pages (from-to)285-292
Number of pages8
Issue number4
Publication statusPublished - 2015


  • 乳癌
  • 組織微陣列
  • glypican-3
  • breast cancer
  • tissue microarray


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