TY - JOUR
T1 - Glycine N-methyltransferase affects urinary 1-hydroxypyrene and 8-hydroxy-2′-deoxyguanosine levels after PAH exposure
AU - Chen, Marcelo
AU - Ho, Chiao Wei
AU - Huang, Yu Chuen
AU - Wu, Kuen Yuh
AU - Wu, Ming Tseng
AU - Jeng, Hueiwang Anna
AU - Chen, Chiou Jong
AU - Shih, Tung Sheng
AU - Lai, Ching Huang
AU - Pan, Chih Hong
AU - Chen, Yi Ming Arthur
N1 - Funding Information:
This study was supported by the Institute of Occupational Safety and Health, Council of Labor Affairs, Taiwan (IOSH94-M101).
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Objectives: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Methods: The study participants included 289 coke-oven workers from a steel company in Taiwan. Personal air samples, spot urine samples, peripheral blood samples, and questionnaires were used to quantify PAH exposure, oxidative DNA damage, GNMT gene polymorphisms, demographic data, and environmental pollutants. Results: Urinary 1-OHP level, GNMT STRP1 genotype, and worksite were significant predictors of urinary 8-OHdG levels after adjustments were made for covariates. Conclusions: This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs.
AB - Objectives: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Methods: The study participants included 289 coke-oven workers from a steel company in Taiwan. Personal air samples, spot urine samples, peripheral blood samples, and questionnaires were used to quantify PAH exposure, oxidative DNA damage, GNMT gene polymorphisms, demographic data, and environmental pollutants. Results: Urinary 1-OHP level, GNMT STRP1 genotype, and worksite were significant predictors of urinary 8-OHdG levels after adjustments were made for covariates. Conclusions: This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs.
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U2 - 10.1097/JOM.0b013e318222b79a
DO - 10.1097/JOM.0b013e318222b79a
M3 - Article
AN - SCOPUS:79960835816
SN - 1076-2752
VL - 53
SP - 812
EP - 819
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 7
ER -
