Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila

Zhao Ying Ding, Ying Hsuan Wang, Zhao Kai Luo, Huei Fang Lee, Jaulang Hwang, Cheng Ting Chien, Min Lang Huang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Axon guidance needs help from the glial cell system during embryogenesis. In the Drosophila embryonic central nervous system (CNS), longitudinal glia (LG) have been implicated in axon guidance but the mechanism remains unclear. We identified the protein encoded by the Drosophila gene unzipped (uzip) as a novel cell adhesion molecule (CAM). Uzip expressed in Drosophila S2 cells triggered cell aggregation through homophilic binding. In the embryonic CNS, Uzip was mainly produced by the LG but was also located at axons, which is consistent with the secretion of Uzip expressed in cultured cells. Although uzip mutants displayed no axonal defect, loss of uzip enhanced the axonal defects in the mutant of N-cadherin (CadN) and the Wnt gene family member wnt5. Overexpression of uzip could rescue the phenotype in the CadNuzipD43 mutant. Thus, Uzip is a novel CAM from the LG regulating axon guidance.

Original languageEnglish
Pages (from-to)122-134
Number of pages13
JournalDevelopmental Dynamics
Issue number1
Publication statusPublished - Jan 2011
Externally publishedYes


  • Adhesion
  • Axon guidance
  • CAM
  • Drosophila
  • Glia
  • Unzipped

ASJC Scopus subject areas

  • Developmental Biology


Dive into the research topics of 'Glial cell adhesive molecule unzipped mediates axon guidance in Drosophila'. Together they form a unique fingerprint.

Cite this