Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

I-Chan Lin; Yuan-Hung Wang; Tsung-Jen Wang; I. Jong Wang; Yun Den Shen; Nai-Fang Chi; Li-Nien Chien

doi:10.1371/journal.pone.0108938

Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

I-Chan Lin, Yuan-Hung Wang, Tsung-Jen Wang, I. Jong Wang, Yun Den Shen, Nai-Fang Chi, Li-Nien Chien

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Abstract

BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.

OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.

METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.

RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).

CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

Original language	English
Article number	08938
Journal	PLoS ONE
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0108938
Publication status	Published - Oct 2 2014

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title = "Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study",

abstract = "BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.",

author = "I-Chan Lin and Yuan-Hung Wang and Tsung-Jen Wang and Wang, {I. Jong} and Shen, {Yun Den} and Nai-Fang Chi and Li-Nien Chien",

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T1 - Glaucoma, Alzheimer's disease, and Parkinson's disease

T2 - An 8-year population-based follow-up study

AU - Lin, I-Chan

AU - Wang, Yuan-Hung

AU - Wang, Tsung-Jen

AU - Wang, I. Jong

AU - Shen, Yun Den

AU - Chi, Nai-Fang

AU - Chien, Li-Nien

PY - 2014/10/2

Y1 - 2014/10/2

N2 - BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

AB - BACKGROUND: Glaucoma is the leading cause of irreversible blindness worldwide and primary open-angle glaucoma (POAG) is the most common type of glaucoma. An association between POAG and the subsequent risk of Alzheimer's disease (AD) and Parkinson's disease (PD) was unclear.OBJECTIVE: To investigate the association between POAG (including normal-tension glaucoma) and the subsequent risk of AD or PD 8 years following a diagnosis of POAG.METHODS: We performed a retrospective, propensity-score-matched analysis of a population-based cohort consisting of patients with and without POAG aged 60 years and older. Control patients without POAG were propensity-score matched to POAG patients based on their baseline characteristics.RESULTS: The incidence rates and confidence intervals (CIs) of AD among the patients with and without POAG were 2.85 (95% CI: 2.19-3.70) and 1.98 (95% CI: 1.68-2.31) per 1000 person-years, respectively. The incidence rates of PD among the POAG and non-POAG cohorts were 4.36 (95% CI: 3.52-5.39) and 4.37 (95% CI: 3.92-4.86) per 1000 person-years, respectively. Kaplan-Meier failure curves showed that the POAG patients had a higher risk of AD than the control patients did (log-rank test, P= .0189). However, the cumulative PD hazard ratios for the POAG and non-POAG patients did not differ significantly (log-rank test, P= .9953).CONCLUSION: In elderly patients, POAG is a significant predictor of AD, but POAG is not a predictor of PD.

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JF - PLoS ONE

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Glaucoma, Alzheimer's disease, and Parkinson's disease: An 8-year population-based follow-up study

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