Ginseng Flowers Stimulate Progesterone Production from Bovine Luteal Cells

Leang Shin Wu, Shiow Yunn Sheu, Cheng Chun Huang, Chih Hsien Chiu, Jan Chi Huang, Jenn Rong Yang, Wai Xiong Lian, Chih Hao Lai, Yuh Pan Chen, Jen Hsou Lin

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11 Citations (Scopus)


Our previous report first showed evidence that polysaccharides isolated from ginseng leaves obtained from Jilin, China possess luteotropic activities. In this study, we made further investigations on the root and flowers of Korean ginseng by means of the same bioassay system described briefly as follows. Frozen-thawed bovine luteal cells (1 × 105 cells/ml/well) in M199 were incubated in 24-well culture plates at 37°C in a 5 % CO2 incubator. Ten μl of tested drugs with 1,10 and 100 μg/ml were added into each well. After 4- and 24-hr incubation, the media were harvested and assayed for progesterone by an enzyme immunoassay. The production of progesterone from cells is the indicator for evaluating the action of tested drugs. Results showed that hot water extracts of ginseng flowers (GF-1 ) with 10 to 100 μg/ml significantly increased progesterone production, whereas those from ginseng root (GR-1) could not. Crude polysaccharides (GF-2) isolated from GF-1 is the active component and the small molecules (mw < 10,000 dalton) are excluded, indicating that the ginseng root has no luteotropic activities, but the polysaccharides of ginseng flowers have.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalAmerican Journal of Chinese Medicine
Issue number3-4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Complementary and alternative medicine


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