Giant cell tumor of soft tissues of neck

We report a case of giant cell tumor of soft tissues of the neck in a 32-year-old woman with a 2-year history of painless neck mass. MRI showed an enhancing mass about 2.1 X 1.7 cm in size in the left cervical posterior paraspinal space. Intraoperatively, a well-encapsulated tumor was found adjacent to the spinous process of the third cervical spine. Histological features showed characteristic dispersed multinucleated giant cells admixed with mononuclear cells. Immunohistochemical staining was positive for CD68 and vimentin, but negative for desmin, smooth muscle actin and S-100 protein. Both mitotic activity and Ki-67 proliferation index were exceedingly low. These features were consistent with giant cell tumor of soft tissues with low-grade potential. Marginal excision was performed due to its proximity to vital structures. She was free of local recurrence after 15-month follow-up. A brief review of the literature of giant cell tumor of soft tissues of the neck was also presented.