Germinoma involving the basal ganglia in children

Tai Tong Wong, Y. W. Chen, Wan Yuo Guo, Kai Ping Chang, Donald M. Ho, Sang Hue Yen

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Background: Germinoma originating in the basal ganglia is rare, and the majority of reported papers have been from Japan. In a collection of the first 500 cases of primary brain tumors in children in Taipei Veterans General Hospital, six pure germinomas with tissue diagnosis situated in this location. Materials and methods: We reviewed the clinical features, neuroimaging studies, tumor markers, management, and outcome of these six patients. Results: All of them were boys. The median age of onset of symptoms was 9.7 years. They uniformly presented with hemiparesis. The average duration of symptoms before surgical management was 1 year. One patient had bilateral basal ganglia tumors. Serum β-human chorionic gonadotropin levels was elevated (128 mIU/ml) in one patient. Longitudinal neuroimaging studies in four patients clearly showed that the tumor arose as a tiny lesion at the lenticular nucleus. Five patients had cysts within tumors. Five patients received partial, subtotal, to total resection. One patient had stereotactic biopsy of the tumors. Postoperative primary adjuvant therapies included radiotherapy, chemotherapy alone, and combined chemotherapy and radiotherapy. Five patients survived, and one patient died of radiation-induced sarcoma with median follow-up period of 13.7 years. Local recurrence was observed in all of three patients after solitary postoperative chemotherapy. Conclusions: The lenticular nucleus is a significant locus for germinomas and can be bilateral. Although rarely reported in Western countries, it does exist in Taiwan as well. Treatment of germinomas in this specific location is similar to germinoma in other intracranial locations.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalChild's Nervous System
Issue number1
Publication statusPublished - Jan 2008
Externally publishedYes


  • Basal ganglia
  • Children
  • Germinoma
  • Intracranial

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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