Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study

Ruey Yun Wang; Chia Min Chung; Cathy S.J. Fann; Hsin Chou Yang; Jaw Wen Chen; Yuh Shiun Jong; Yuh Shan Jou; Huey Ming Lo; Feng Ming Ho; Chih Sen Kang; Chien Chung Chen; Huan Cheng Chang; Song Kun Shyue; Wen Harn Pan

doi:10.1159/000108940

Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study

Ruey Yun Wang, Chia Min Chung, Cathy S.J. Fann, Hsin Chou Yang, Jaw Wen Chen, Yuh Shiun Jong, Yuh Shan Jou, Huey Ming Lo, Feng Ming Ho, Chih Sen Kang, Chien Chung Chen, Huan Cheng Chang, Song Kun Shyue, Wen Harn Pan

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Objectives: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). Methods: With 1,271 individuals from 373 young-onset (age ≤40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.

Original language	English
Pages (from-to)	85-90
Number of pages	6
Journal	Human Heredity
Volume	65
Issue number	2
DOIs	https://doi.org/10.1159/000108940
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

Angiotensin converting enzyme
Chinese
Genome-wide scan
Hypertension
Quantitative trait loci
Taiwan

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000108940

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title = "Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study",

abstract = "Objectives: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). Methods: With 1,271 individuals from 373 young-onset (age ≤40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.",

keywords = "Angiotensin converting enzyme, Chinese, Genome-wide scan, Hypertension, Quantitative trait loci, Taiwan",

author = "Wang, {Ruey Yun} and Chung, {Chia Min} and Fann, {Cathy S.J.} and Yang, {Hsin Chou} and Chen, {Jaw Wen} and Jong, {Yuh Shiun} and Jou, {Yuh Shan} and Lo, {Huey Ming} and Ho, {Feng Ming} and Kang, {Chih Sen} and Chen, {Chien Chung} and Chang, {Huan Cheng} and Shyue, {Song Kun} and Pan, {Wen Harn}",

year = "2007",

month = nov,

doi = "10.1159/000108940",

language = "English",

volume = "65",

pages = "85--90",

journal = "Human Heredity",

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TY - JOUR

T1 - Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study

AU - Wang, Ruey Yun

AU - Chung, Chia Min

AU - Fann, Cathy S.J.

AU - Yang, Hsin Chou

AU - Chen, Jaw Wen

AU - Jong, Yuh Shiun

AU - Jou, Yuh Shan

AU - Lo, Huey Ming

AU - Ho, Feng Ming

AU - Kang, Chih Sen

AU - Chen, Chien Chung

AU - Chang, Huan Cheng

AU - Shyue, Song Kun

AU - Pan, Wen Harn

PY - 2007/11

Y1 - 2007/11

N2 - Objectives: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). Methods: With 1,271 individuals from 373 young-onset (age ≤40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.

AB - Objectives: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). Methods: With 1,271 individuals from 373 young-onset (age ≤40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.

KW - Angiotensin converting enzyme

KW - Chinese

KW - Genome-wide scan

KW - Hypertension

KW - Quantitative trait loci

KW - Taiwan

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Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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