Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study

Ruey Yun Wang, Chia Min Chung, Cathy S.J. Fann, Hsin Chou Yang, Jaw Wen Chen, Yuh Shiun Jong, Yuh Shan Jou, Huey Ming Lo, Feng Ming Ho, Chih Sen Kang, Chien Chung Chen, Huan Cheng Chang, Song Kun Shyue, Wen Harn Pan

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Objectives: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). Methods: With 1,271 individuals from 373 young-onset (age ≤40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalHuman Heredity
Issue number2
Publication statusPublished - Nov 2007
Externally publishedYes


  • Angiotensin converting enzyme
  • Chinese
  • Genome-wide scan
  • Hypertension
  • Quantitative trait loci
  • Taiwan

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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