TY - JOUR
T1 - Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Malignant Neoplasms of the Brain in Taiwan
AU - Lin, Jang Chun
AU - Wu, Yi Chieh
AU - Yang, Fu Chi
AU - Tsai, Jo Ting
AU - Huang, David Y.C.
AU - Liu, Wei Hsiu
N1 - Funding Information:
We thank all the participants and investigators from Taiwan Precision Medicine Initiative. This study was funded by Academia Sinica 40-05-GMM and AS-GC-110-MD02. We also thank the Center for Precision Medicine and Genomic (CPMG), Tri-Service General Hospital, National Defense Medical Center for helping us in gene information support.
Funding Information:
This research was funded by the Tri-Service General Hospital (TSGH-E111226 to W.-H.L.) and the Ministry of Science and Technology (MOST 109-2314-B-016-016-MY2 to W.-H.L.).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/7
Y1 - 2022/7
N2 - Primary brain malignancy is a rare tumor with a global incidence of less than 10 per 100,000 people. Hence, there is limited power for identifying risk loci in individual studies, especially for Han Chinese. We performed a genome-wide association study (GWAS) in Taiwan, including 195 cases and 195 controls. We identified five new genes for malignant neoplasms of the brain: EDARADD (rs645507, 1p31.3, p = 7.71 × 10−5, odds ratio (OR) = 1.893), RBFOX1 (rs8044700, p = 2.35 × 10−5, OR = 2.36), LMF1 (rs3751667, p = 7.24 × 10−7, OR = 2.17), DPP6 (rs67433368, p = 8.32 × 10−5, OR = 3.94), and NDUFB9 (rs7827791, p = 9.73 × 10−6, OR = 4.42). These data support that genetic susceptibility toward GBM or non-GBM tumors is highly distinct, likely reflecting different etiologies. Combined with signaling analysis, we found that RNA modification may be related to major risk factors in primary malignant neoplasms of the brain.
AB - Primary brain malignancy is a rare tumor with a global incidence of less than 10 per 100,000 people. Hence, there is limited power for identifying risk loci in individual studies, especially for Han Chinese. We performed a genome-wide association study (GWAS) in Taiwan, including 195 cases and 195 controls. We identified five new genes for malignant neoplasms of the brain: EDARADD (rs645507, 1p31.3, p = 7.71 × 10−5, odds ratio (OR) = 1.893), RBFOX1 (rs8044700, p = 2.35 × 10−5, OR = 2.36), LMF1 (rs3751667, p = 7.24 × 10−7, OR = 2.17), DPP6 (rs67433368, p = 8.32 × 10−5, OR = 3.94), and NDUFB9 (rs7827791, p = 9.73 × 10−6, OR = 4.42). These data support that genetic susceptibility toward GBM or non-GBM tumors is highly distinct, likely reflecting different etiologies. Combined with signaling analysis, we found that RNA modification may be related to major risk factors in primary malignant neoplasms of the brain.
KW - brain cancer
KW - glioma
KW - LMF1
KW - RBFOX1
KW - SNP
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U2 - 10.3390/jpm12071161
DO - 10.3390/jpm12071161
M3 - Article
AN - SCOPUS:85136236218
SN - 2075-4426
VL - 12
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 7
M1 - 1161
ER -
