TY - JOUR
T1 - Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
AU - Hattori, Takeshi
AU - Konno, Satoshi
AU - Takahashi, Ayumu
AU - Isada, Akira
AU - Shimizu, Kaoruko
AU - Shimizu, Kenichi
AU - Taniguchi, Natsuko
AU - Gao, Peisong
AU - Yamaguchi, Etsuro
AU - Hizawa, Nobuyuki
AU - Huang, Shau Ku
AU - Nishimura, Masaharu
PY - 2010/10/28
Y1 - 2010/10/28
N2 - Background: Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis.Methods: Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls.Results: Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001).Conclusions: These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.
AB - Background: Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis.Methods: Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls.Results: Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001).Conclusions: These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.
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U2 - 10.1186/1471-2350-11-151
DO - 10.1186/1471-2350-11-151
M3 - Article
C2 - 21029423
AN - SCOPUS:77958556482
SN - 1755-8794
VL - 11
JO - BMC Medical Genetics
JF - BMC Medical Genetics
IS - 1
M1 - 151
ER -