TY - JOUR
T1 - Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension
AU - Hsueh, Yu Mei
AU - Lin, Pinpin
AU - Chen, Hui Wen
AU - Shiue, Horng Sheng
AU - Chung, Chi Jung
AU - Tsai, Chiao Tzu
AU - Huang, Yung Kay
AU - Chiou, Hung Yi
AU - Chen, Chien Jen
N1 - Funding Information:
This study was supported by grants NSC-86-2314-B-038-038, NSC-87-2314-B-038-029, NSC-88-2314-B-038-112, NSC-88-2318-B-038-002-M51, NSC-89-2320-B-038-013, NSC-89-2318-B-038-M51, NSC-89-2314-B-038-049, NSC-90-2320-B-038-021, NSC-90-2320-B-002-197, NSC-90-2320-B-038-021, NSC-91-3112-B-038-001, NSC-92-2320-B-002-156, NSC-92-3112-B-038-001, and NSC-92-2321-B-038-004 from the National Science Council of the ROC.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/9/10
Y1 - 2005/9/10
N2 - The association of 4 genetic polymorphisms, NAD(P)H oxidase, manganese superoxide dismutase (MnSOD), catalase, and endothelial nitric oxide synthase (e-NOS), was assessed with arsenic-related hypertension risk among 79 hypertensive cases and 213 controls in an arseniasis-hyperendemic area of Taiwan. Overall, MnSOD polymorphism significantly increased the risk of hypertension regardless of arsenic exposure. NADPH oxidase and eNOS polymorphisms were significantly associated with hypertension risk in the high arsenic exposure group; however, catalase polymorphism was not associated with hypertension. Groups were further stratified by triglyceride levels to evaluate whether the cumulative arsenic exposure combined the three polymorphisms together. The adjusted adds ratios (ORs) of at least two risk factors of the cumulative arsenic exposure and MnSOD, NADPH oxidase, and eNOS three-polymorphism combination versus any one risk factor of them were 0.8 (95% CI 0.3-2.3) for individuals with low triglyceride levels (<110 mg/dl) and 2.5 (95% CI 1.0-6.01) for high-triglyceride groups (> 110 mg/dl), respectively. These results suggested that the NADPH oxidase, MnSOD, and e-NOS polymorphisms, but not catalase, might play a role in the development of arsenic-related hypertension, especially in subjects with high triglyceride levels. Copyright
AB - The association of 4 genetic polymorphisms, NAD(P)H oxidase, manganese superoxide dismutase (MnSOD), catalase, and endothelial nitric oxide synthase (e-NOS), was assessed with arsenic-related hypertension risk among 79 hypertensive cases and 213 controls in an arseniasis-hyperendemic area of Taiwan. Overall, MnSOD polymorphism significantly increased the risk of hypertension regardless of arsenic exposure. NADPH oxidase and eNOS polymorphisms were significantly associated with hypertension risk in the high arsenic exposure group; however, catalase polymorphism was not associated with hypertension. Groups were further stratified by triglyceride levels to evaluate whether the cumulative arsenic exposure combined the three polymorphisms together. The adjusted adds ratios (ORs) of at least two risk factors of the cumulative arsenic exposure and MnSOD, NADPH oxidase, and eNOS three-polymorphism combination versus any one risk factor of them were 0.8 (95% CI 0.3-2.3) for individuals with low triglyceride levels (<110 mg/dl) and 2.5 (95% CI 1.0-6.01) for high-triglyceride groups (> 110 mg/dl), respectively. These results suggested that the NADPH oxidase, MnSOD, and e-NOS polymorphisms, but not catalase, might play a role in the development of arsenic-related hypertension, especially in subjects with high triglyceride levels. Copyright
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U2 - 10.1080/15287390590967414
DO - 10.1080/15287390590967414
M3 - Article
C2 - 16076760
AN - SCOPUS:26044453568
SN - 1528-7394
VL - 68
SP - 1471
EP - 1484
JO - Journal of Toxicology and Environmental Health - Part A
JF - Journal of Toxicology and Environmental Health - Part A
IS - 17-18
ER -