Genetic polymorphisms in Kawasaki disease

Ho Chang Kuo, Wei Chiao Chang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Kawasaki disease (KD) is an acute febrile systemic vasculitis, and the cause of KD is not well understood. It is likely due to multiple interactions between genes and environmental factors. The development of genetic association and genome-wide association studies (GWAS) has opened an avenue to better understanding the molecular mechanisms underlying KD. A novel ITPKC signaling pathway was recently found to be responsible for the susceptibility to KD. Furthermore, the GWAS demonstrated the functionally related susceptibility loci for KD in the Caucasian population. In the last decade, the identification of several genomic regions linked to the pathogenesis of KD has made a major breakthrough in understanding the genetics of KD. This review will focus on genetic polymorphisms associated with KD and describe some of the possible clinical implications and molecular mechanisms that can be used to explain how genetic variants regulate the pathogenesis in KD.

Original languageEnglish
Pages (from-to)1193-1198
Number of pages6
JournalActa Pharmacologica Sinica
Issue number10
Publication statusPublished - Oct 2011
Externally publishedYes


  • coronary artery lesions
  • genetics
  • intravenous immunoglobulin
  • Kawasaki disease
  • SNP

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


Dive into the research topics of 'Genetic polymorphisms in Kawasaki disease'. Together they form a unique fingerprint.

Cite this