Generation of the probabilistic template of default mode network derived from resting-state fMRI

Defeng Wang, You-Yong Kong, Winnie Chiu-Wing Chu, Cindy Woon-Chi Tam, Linda Chiu-Wa Lam, Yi-Long Wang, Georg Franz Josef Northoff, Yi-Long Wang, Lin Shi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Default-mode network (DMN) has become a prominent network among all large-scale brain networks which can be derived from the resting-state fMRI (rs-fMRI) data. Statistical template labeling the common location of hubs in DMN is favorable in the identification of DMN from tens of components resulted from the independent component analysis (ICA). This paper proposed a novel iterative framework to generate a probabilistic DMN template from a coherent group of 40 healthy subjects. An initial template was visually selected from the independent components derived from group ICA analysis of the concatenated rs-fMRI data of all subjects. An effective similarity measure was designed to choose the best-fit component from all independent components of each subject computed given different component numbers. The selected DMN components for all subjects were averaged to generate an updated DMN template and then used to select the DMN for each subject in the next iteration. This process iterated until the convergence was reached, i.e., the overlapping region between the DMN areas of the current template and the one generated from the previous stage is more than 95%. By validating the constructed DMN template on the rs-fMRI data from another 40 subjects, the generated probabilistic DMN template and the proposed similarity matching mechanism were demonstrated to be effective in automatic selection of independent components from the ICA analysis results. © 1964-2012 IEEE.
Original languageEnglish
Pages (from-to)2550-2555
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Issue number10
Publication statusPublished - 2014
Externally publishedYes


  • Brain network
  • default mode network (DMN)
  • resting-state fMRI (rs-fMRI)
  • template
  • Data visualization
  • Independent component analysis
  • Brain networks
  • Default mode network (DMN)
  • Default-mode networks
  • Independent component analysis(ICA)
  • Independent components
  • Overlapping regions
  • Resting-state fmri
  • Functional neuroimaging
  • adult
  • aged
  • algorithm
  • Article
  • brain mapping
  • default mode network
  • female
  • functional magnetic resonance imaging
  • functional neuroimaging
  • human
  • independent component analysis
  • male
  • normal human
  • nuclear magnetic resonance scanner
  • time series analysis
  • anatomy and histology
  • biological model
  • brain
  • image processing
  • middle aged
  • nuclear magnetic resonance imaging
  • physiology
  • procedures
  • statistical model
  • very elderly
  • Aged
  • Aged, 80 and over
  • Algorithms
  • Brain
  • Brain Mapping
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Models, Neurological
  • Models, Statistical


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