Gene expression signature-based approach identifies antifungal drug ciclopirox as a novel inhibitor of hmga2 in colorectal cancer

Medicine & Life Sciences

• Ciclopirox 82%
• varespladib methyl 53%
• Transcriptome 46%
• Colorectal Neoplasms 40%
• HSP90 Heat-Shock Proteins 22%
• Pharmaceutical Preparations 21%
• 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide 10%
• AT-Hook Motifs 9%
• Drug Repositioning 7%
• Amino Acid Motifs 7%
• Apoptosis 6%
• Antifungal Agents 6%
• DNA-Binding Proteins 6%
• Cell Cycle Checkpoints 5%
• Biological Phenomena 5%
• DNA Repair 5%
• Libraries 4%
• Chromatin 4%
• DNA Damage 4%
• Cell Cycle 4%
• Carcinogenesis 4%
• Neoplasms 3%
• Databases 3%
• Gene Expression 3%
• Therapeutics 2%
• In Vitro Techniques 2%
• Proteins 2%

Chemical Compounds

• Ciclopirox 100%
• Hsp90 Inhibitor 53%
• Drug 26%
• Protein 13%
• Heat 12%