Gender differences in genetic associations of RAB38 with urinary protein-to-creatinine ratio (UPCR) levels in diabetic nephropathy patients

Zhi Lei Yu; Chung Shun Wong; Yi Ting Lai; Wan Hsuan Chou; Imaniar Noor Faridah; Chih Chin Kao; Yuh Feng Lin; Wei Chiao Chang

doi:10.3390/jpm10040184

Gender differences in genetic associations of RAB38 with urinary protein-to-creatinine ratio (UPCR) levels in diabetic nephropathy patients

Zhi Lei Yu, Chung Shun Wong, Yi Ting Lai, Wan Hsuan Chou, Imaniar Noor Faridah, Chih Chin Kao, Yuh Feng Lin, Wei Chiao Chang

Research output: Contribution to journal › Article › peer-review

Abstract

Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis ofGWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.

Original language	English
Article number	184
Pages (from-to)	1-12
Number of pages	12
Journal	Journal of Personalized Medicine
Volume	10
Issue number	4
DOIs	https://doi.org/10.3390/jpm10040184
Publication status	Published - Dec 2020

Keywords

Albuminuria
DM(diabetesmellitus)
DN(diabeticnephropathy)
Geneticpolymorphism
RAB38

ASJC Scopus subject areas

Medicine (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jpm10040184

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@article{ebb8dc4d29f74533a27202c6bd28d618,

title = "Gender differences in genetic associations of RAB38 with urinary protein-to-creatinine ratio (UPCR) levels in diabetic nephropathy patients",

abstract = "Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis ofGWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.",

keywords = "Albuminuria, DM(diabetesmellitus), DN(diabeticnephropathy), Geneticpolymorphism, RAB38",

author = "Yu, {Zhi Lei} and Wong, {Chung Shun} and Lai, {Yi Ting} and Chou, {Wan Hsuan} and Faridah, {Imaniar Noor} and Kao, {Chih Chin} and Lin, {Yuh Feng} and Chang, {Wei Chiao}",

note = "Funding Information: Funding: This work was supported by grants from the Ministry of Science and Technology, Taiwan (105-2628-B-038-001-MY4), and Taipei Medical University (105TMU-CIT-02-3, 106TMU-CIT-02-3, and TMU108-AE1-B21). Funding Information: Acknowledgments: The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The data used for the analyses described in this manuscript were obtained from the GTEx Portal on 22 June 2020. Publisher Copyright: {\textcopyright} 2020 by the authors. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = dec,

doi = "10.3390/jpm10040184",

language = "English",

volume = "10",

pages = "1--12",

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T1 - Gender differences in genetic associations of RAB38 with urinary protein-to-creatinine ratio (UPCR) levels in diabetic nephropathy patients

AU - Yu, Zhi Lei

AU - Wong, Chung Shun

AU - Lai, Yi Ting

AU - Chou, Wan Hsuan

AU - Faridah, Imaniar Noor

AU - Kao, Chih Chin

AU - Lin, Yuh Feng

AU - Chang, Wei Chiao

N1 - Funding Information: Funding: This work was supported by grants from the Ministry of Science and Technology, Taiwan (105-2628-B-038-001-MY4), and Taipei Medical University (105TMU-CIT-02-3, 106TMU-CIT-02-3, and TMU108-AE1-B21). Funding Information: Acknowledgments: The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The data used for the analyses described in this manuscript were obtained from the GTEx Portal on 22 June 2020. Publisher Copyright: © 2020 by the authors. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis ofGWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.

AB - Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis ofGWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.

KW - Albuminuria

KW - DM(diabetesmellitus)

KW - DN(diabeticnephropathy)

KW - Geneticpolymorphism

KW - RAB38

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M1 - 184

ER -

Gender differences in genetic associations of RAB38 with urinary protein-to-creatinine ratio (UPCR) levels in diabetic nephropathy patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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