Gastroesophageal Reflux Disease and Atrial Fibrillation: A Nationwide Population-Based Study

Chin Chou Huang, Wan Leong Chan, Jiing Chyuan Luo, Yu Chun Chen, Tzeng Ji Chen, Chia Min Chung, Po Hsun Huang, Shing Jong Lin, Jaw Wen Chen, Hsin Bang Leu

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Objectives: Precise mechanisms of atrial fibrillation (AF) are uncertain, but their association with esophageal disorders has been recently proposed. The association between gastroesophageal reflux disease (GERD), the most common gastroesophageal disorder, and AF remains undetermined. We therefore aimed to investigate the association between GERD and later development of AF. Methods and Results: Patients with GERD were identified from the 1,000,000-person cohort dataset sampled from the Taiwan National Health Insurance database. The study cohort comprised 29,688 newly diagnosed adult GERD patients; 29,597 randomly selected age-, gender-, comobidity-matched subjects comprised the comparison cohort. Cox proportional hazard regressions were performed as a means of comparing the AF-free survival rate for the two cohorts. During a maximum three years of follow-up, a total of 351 patients experienced AF, including 184 (0.62%) patients in the GERD cohort and 167 (0.56%) in the control group. The log-rank test showed that patients with GERD had significantly higher incidence of AF than those without GERD (p = 0.024). After Cox proportional hazard regression model analysis, GERD was independently associated with the increased risk of AF (hazard ratio, 1.31; 95% confidence interval, 1.06-1.61, p = 0.013). Conclusion: GERD was independently associated with an increased risk of future AF in a nationwide population-based cohort.

Original languageEnglish
Article numbere47575
JournalPLoS ONE
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 15 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General

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