TY - JOUR
T1 - Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis
AU - Wu, Yu Hsueh
AU - Chang, Julia Yu Fong
AU - Wang, Yi Ping
AU - Wu, Yang Che
AU - Chen, Hsin Ming
AU - Sun, Andy
N1 - Publisher Copyright:
© 2018
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG + RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG + RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG + RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG + RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. Conclusion: AG + RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.
AB - Background/Purpose: Behcet's disease (BD) patients should have recurrent aphthous stomatitis (RAS) but they may or may not have atrophic glossitis (AG). This study mainly assessed the frequencies of serum gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) positivities in 30 AG-positive RAS/BD (AG + RAS/BD) and 33 AG-negative RAS/BD (AG־RAS/BD) patients. Methods: The frequencies of serum GPCA, TGA, and TMA positivities in 30 AG + RAS/BD patients, 33 AG־RAS/BD patients, and 126 healthy control subjects were calculated and compared. Results: We found that 20.0%, 30.0%, and 26.7% of 30 AG + RAS/BD patients, 9.1%, 12.1%, and 15.2% of 33 AG־RAS/BD patients, and 1.6%, 2.4%, and 2.4% of 126 healthy control subject had the presence of GPCA, TGA, and TMA in their sera, respectively. The 30 AG + RAS/BD patients had significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). The 33 AG־RAS/BD patients had a higher frequency of serum TGA positivity (P = 0.051, marginal significance) and a significantly higher frequency of serum TMA positivity (P = 0.011) than healthy control subjects. Although the 30 AG + RAS/BD patients had higher frequencies of serum GPCA, TGA, and TMA positivities than the 33 AG־RAS/BD patients, the differences were not significant. Conclusion: AG + RAS/BD patients do have significantly higher frequencies of serum GPCA, TGA, and TMA positivities than healthy control subjects. This finding indicates that the concomitant presence of AG may result in significantly elevated frequencies of serum GPCA, TGA, and TMA positivities in BD patients.
KW - Atrophic glossitis
KW - Behcet's disease
KW - Gastric parietal cell antibody
KW - Recurrent aphthous stomatitis
KW - Thyroglobulin antibody
KW - Thyroid microsomal antibody
UR - http://www.scopus.com/inward/record.url?scp=85045571582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045571582&partnerID=8YFLogxK
U2 - 10.1016/j.jfma.2018.03.015
DO - 10.1016/j.jfma.2018.03.015
M3 - Article
C2 - 29653880
AN - SCOPUS:85045571582
SN - 0929-6646
VL - 117
SP - 691
EP - 696
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
IS - 8
ER -