Gallstone disease and the risk of stroke: A nationwide population-based study

Cheng Yu Wei; Tieh Chi Chung; Chien Hua Chen; Che Chen Lin; Fung Chang Sung; Wen Ting Chung; Woon Man Kung; Chung Y. Hsu; Yung Hsiang Yeh

doi:10.1016/j.jstrokecerebrovasdis.2014.04.024

Gallstone disease and the risk of stroke: A nationwide population-based study

Cheng Yu Wei, Tieh Chi Chung, Chien Hua Chen, Che Chen Lin, Fung Chang Sung, Wen Ting Chung, Woon Man Kung, Chung Y. Hsu, Yung Hsiang Yeh

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Background Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD. Methods Data were obtained from the Taiwan National Health Insurance Research Database. A total of 135,512 patients with a diagnosis of GD and 271,024 age- and gender-matched non-GD control patients were included to assess the risk of stroke using Cox proportional hazard regression. Results During the study period (2000-2003), 12,234 (153.67/10,000 person-years) strokes occurred among the GD patients, and 20,680 (114.83/10,000 person-years) among the controls. The diagnosis of GD carried a higher risk of developing ischemic and hemorrhagic stroke, with a hazard ratio (HR) of 1.28 and 1.33 (95% confidence interval [CI], 1.25-1.31 and 1.25-1.41, both P

Original language	English
Pages (from-to)	1813-1820
Number of pages	8
Journal	Journal of Stroke and Cerebrovascular Diseases
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.024
Publication status	Published - 2014
Externally published	Yes

Keywords

cholelithiasis
epidemiology
gallstone disease
risk factors
Stroke

ASJC Scopus subject areas

Clinical Neurology
Surgery
Rehabilitation
Cardiology and Cardiovascular Medicine
General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jstrokecerebrovasdis.2014.04.024

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title = "Gallstone disease and the risk of stroke: A nationwide population-based study",

abstract = "Background Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD. Methods Data were obtained from the Taiwan National Health Insurance Research Database. A total of 135,512 patients with a diagnosis of GD and 271,024 age- and gender-matched non-GD control patients were included to assess the risk of stroke using Cox proportional hazard regression. Results During the study period (2000-2003), 12,234 (153.67/10,000 person-years) strokes occurred among the GD patients, and 20,680 (114.83/10,000 person-years) among the controls. The diagnosis of GD carried a higher risk of developing ischemic and hemorrhagic stroke, with a hazard ratio (HR) of 1.28 and 1.33 (95% confidence interval [CI], 1.25-1.31 and 1.25-1.41, both P ",

keywords = "cholelithiasis, epidemiology, gallstone disease, risk factors, Stroke",

author = "Wei, {Cheng Yu} and Chung, {Tieh Chi} and Chen, {Chien Hua} and Lin, {Che Chen} and Sung, {Fung Chang} and Chung, {Wen Ting} and Kung, {Woon Man} and Hsu, {Chung Y.} and Yeh, {Yung Hsiang}",

year = "2014",

doi = "10.1016/j.jstrokecerebrovasdis.2014.04.024",

language = "English",

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journal = "Journal of Stroke and Cerebrovascular Diseases",

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T1 - Gallstone disease and the risk of stroke

T2 - A nationwide population-based study

AU - Wei, Cheng Yu

AU - Chung, Tieh Chi

AU - Chen, Chien Hua

AU - Lin, Che Chen

AU - Sung, Fung Chang

AU - Chung, Wen Ting

AU - Kung, Woon Man

AU - Hsu, Chung Y.

AU - Yeh, Yung Hsiang

PY - 2014

Y1 - 2014

N2 - Background Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD. Methods Data were obtained from the Taiwan National Health Insurance Research Database. A total of 135,512 patients with a diagnosis of GD and 271,024 age- and gender-matched non-GD control patients were included to assess the risk of stroke using Cox proportional hazard regression. Results During the study period (2000-2003), 12,234 (153.67/10,000 person-years) strokes occurred among the GD patients, and 20,680 (114.83/10,000 person-years) among the controls. The diagnosis of GD carried a higher risk of developing ischemic and hemorrhagic stroke, with a hazard ratio (HR) of 1.28 and 1.33 (95% confidence interval [CI], 1.25-1.31 and 1.25-1.41, both P

AB - Background Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD. Methods Data were obtained from the Taiwan National Health Insurance Research Database. A total of 135,512 patients with a diagnosis of GD and 271,024 age- and gender-matched non-GD control patients were included to assess the risk of stroke using Cox proportional hazard regression. Results During the study period (2000-2003), 12,234 (153.67/10,000 person-years) strokes occurred among the GD patients, and 20,680 (114.83/10,000 person-years) among the controls. The diagnosis of GD carried a higher risk of developing ischemic and hemorrhagic stroke, with a hazard ratio (HR) of 1.28 and 1.33 (95% confidence interval [CI], 1.25-1.31 and 1.25-1.41, both P

KW - cholelithiasis

KW - epidemiology

KW - gallstone disease

KW - risk factors

KW - Stroke

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Gallstone disease and the risk of stroke: A nationwide population-based study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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