Gallstone disease and the risk of stroke: A nationwide population-based study

Cheng Yu Wei, Tieh Chi Chung, Chien Hua Chen, Che Chen Lin, Fung Chang Sung, Wen Ting Chung, Woon Man Kung, Chung Y. Hsu, Yung Hsiang Yeh

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Background Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD. Methods Data were obtained from the Taiwan National Health Insurance Research Database. A total of 135,512 patients with a diagnosis of GD and 271,024 age- and gender-matched non-GD control patients were included to assess the risk of stroke using Cox proportional hazard regression. Results During the study period (2000-2003), 12,234 (153.67/10,000 person-years) strokes occurred among the GD patients, and 20,680 (114.83/10,000 person-years) among the controls. The diagnosis of GD carried a higher risk of developing ischemic and hemorrhagic stroke, with a hazard ratio (HR) of 1.28 and 1.33 (95% confidence interval [CI], 1.25-1.31 and 1.25-1.41, both P

Original languageEnglish
Pages (from-to)1813-1820
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number7
Publication statusPublished - 2014
Externally publishedYes


  • cholelithiasis
  • epidemiology
  • gallstone disease
  • risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine
  • General Medicine


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